Post-Doctoral Fellow – Mamedov Lab

Wistar Institute; Philadelphia (Philadelphia County); On-site; USD 60,000 - 80,000; Full time

Job summary

The Wistar Institute in Philadelphia invites applications for a Postdoctoral Fellow to join the Mamedov Lab. The work focuses on γδ T cell recognition of cancer cells, CRISPR screens, and functional genomics to understand how the immune system detects tumors.

Applicants should have expertise in one or more of the following areas: T cell biology, cancer immunology, in vitro cancer models, genomics, or gene editing. We offer a competitive salary and comprehensive benefits.

Qualifications

• Postdoctoral fellow with motivation to lead high-impact projects in cancer immunology.
• Expertise in one or more: T cell biology, cancer immunology, in vitro cancer models, genomics, or gene editing.
• Experience with CRISPR screening is a plus.

Responsibilities

• Lead CRISPR screens and functional genomics studies in human γδ T cells.
• Investigate TCR tumor ligand discovery and immune sensing of stress-remodeled cancer cells.
• Collaborate with multidisciplinary teams to advance immunotherapy research.

Job description

The laboratory of Dr. Murad Mamedov at The Wistar Institute is recruiting a Postdoctoral Fellow. The Mamedov Lab uses CRISPR screens and functional genomics to understand how the human immune system detects and kills cancer cells. We focus on understanding how human γδ T cells sense cellular stress in tumors, with the goal of developing novel and broadly accessible immunotherapies.

We are seeking a highly motivated Postdoctoral Fellow to lead high-impact projects focused on T cell receptor (TCR) tumor ligand discovery, CRISPR screening and engineering of human γδ T cells, and T cell detection of stress-remodeled cancer cells. This work will build on and significantly expand beyond our published work on human γδ T cell recognition and killing of cancer cells (Nature, PMID: 37648854). The successful candidate will have expertise in one or more of the following: T cell biology, cancer immunology, in vitro cancer models, genomics, or gene editing.

We offer a competitive salary and an excellent benefits package.

The Wistar Institute is in Philadelphia, in the heart of the University of Pennsylvania campus. Wistar provides resources for cutting-edge collaborative research and provides for outstanding intellectual environments and state-of-the-art facilities. The Wistar Institute is a world leader in early-stage discovery science in the areas of cancer, immunology, and infectious disease. Wistar is committed to accelerating research advances from bench to bedside through brilliant science and distinctive approaches to collaboration among scientific investigators and academic and industry partners. Wistar’s dynamic environment supports the advancement of discoveries that will change the future of human health.

For more information about The Wistar Institute visit our website at www.wistar.org.

It is the policy of the Institute to provide equal employment opportunities to all individuals regardless of race, citizenship, ethnicity, color, creed, religion, marital status, national origin, ancestry, sex, age, veteran status, mental or physical disability (including HIV and AIDS), pregnancy, caregiver status, domestic or sexual violence victim status, sexual orientation, gender identity and expression, or on the basis of genetic information, or any other characteristic protected by federal, state, or local law, with respect to all terms and conditions of employment.