Post-Doctoral Fellow - GZhou Lab

Wistar; Philadelphia (Philadelphia County); On-site; USD 60,000 - 90,000; Full time

Benefits offered by this job

Competitive salary

Excellent benefits package

On-site in Philadelphia

Job summary

The Wistar Institute in Philadelphia invites applications for a Post-Doctoral Fellow to join the Center for Advanced Therapeutics (CAT) in the Zhou lab, developing AI- and physics-based computational methods to accelerate drug discovery.

The successful candidate will work on AI model development, protein–ligand modeling, docking and binding-affinity prediction, and large-scale virtual screening, with opportunities to validate predictions experimentally.

Qualifications

• PhD in computational chemistry, biophysics, computer science or related field.
• At least one first-author peer-reviewed publication.
• Experience in ML/DL, molecular modeling, or related areas is desirable.
• Creative, self-motivated, and collaborative researcher.

Responsibilities

• Develop AI- and physics-based computational methods for drug discovery.
• Pursue AI model development, protein–ligand modeling, docking and binding-affinity prediction, and large-scale virtual screening.
• Collaborate with experimental researchers to validate computational predictions.

Skills

Machine learning

Molecular modeling

Molecular dynamics

Protein modeling

Cheminformatics

Education

PhD in computational chemistry

PhD in biophysics

PhD in computer science

Job description

The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania, United States of America

Job Description

Posted Tuesday, August 18, 2026 at 4:00 AM

The Wistar Institute is recruiting a Post-Doctoral Fellow to work in the laboratory of Dr. Guangfeng Zhou as part of the Center for Advanced Therapeutics (CAT) at The Wistar Institute. The Zhou lab develops physics-based and AI-based computational methods to accelerate therapeutic discovery. His current program focuses on developing AI-based and physics-based computational approaches for drug discovery, including models that integrate physical and chemical principles, docking and binding-affinity prediction methods, and AI-accelerated virtual-screening platforms to identify and prioritize promising therapeutic leads.

We are seeking a highly motivated Post-Doctoral Fellow interested in developing and applying AI and physics-based computational methods for drug discovery. The successful candidate will have opportunities to pursue projects spanning AI model development, protein-ligand modeling, molecular docking and binding-affinity prediction, and large-scale virtual screening. The candidate will also have opportunities to work closely with experimental collaborators to apply newly developed computational methods to challenging therapeutic targets and experimentally validate computational predictions.

Candidates should be nearing completion of or already have a PhD in computational chemistry, biophysics, computer science, or a related field. Candidates should have a strong computational background and at least one first-author peer-reviewed publication. Experience in one or more of the following areas is desirable: machine learning/deep learning, molecular modeling, molecular dynamics, protein structure modeling, cheminformatics, or computational drug discovery. We particularly value candidates who are creative, self-motivated, and interested in developing new computational methods, while working collaboratively with computational and experimental researchers.

We offer a competitive salary and an excellent benefits package.

The Wistar Institute is in Philadelphia, in the heart of the University of Pennsylvania campus. Wistar provides resources for cutting-edge collaborative research and provides for outstanding intellectual environments and state-of-the-art facilities. The Wistar Institute is a world leader in early-stage discovery science in the areas of cancer, immunology, and infectious disease. Wistar is committed to accelerating research advances from bench to bedside through brilliant science and distinctive approaches to collaboration among scientific investigators and academic and industry partners. Wistar’s dynamic environment supports the advancement of discoveries that will change the future of human health.

For more information about The Wistar Institute visit our website atwww.wistar.org .

It is the policy of the Institute to provide equal employment opportunities to all individuals regardless of race, citizenship, ethnicity, color, creed, religion, marital status, national origin, ancestry, sex, age, veteran status, mental or physical disability (including HIV and AIDS), pregnancy, caregiver status, domestic or sexual violence victim status, sexual orientation, gender identity and expression, or on the basis of genetic information, or any other characteristic protected by federal, state, or local law, with respect to all terms and conditions of employment.

The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania, United States of America