Post-Doctoral Fellow

Center for Public Partnerships & Research; Topeka (KS); On-site; USD 53,000 - 65,000; Full time

Job summary

The Center for BioModular Multi-Scale Systems for Precision Medicine (CBMM) at the University of Kansas is seeking a post-doctoral fellow to advance nanotechnology for structural determinations of proteins. The role involves leading graduate students and contributing to NSF-funded research on resistive pulse sensing and peptide analysis.

Ideal candidates hold a Ph.D. in biomedical or chemical engineering or chemistry, with experience in nanopore sensing and related surface chemistries.

Qualifications

• Ph.D. in Biomedical Engineering, Mechanical Engineering, or Chemistry.
• Experience in nanopore sensing and Resistive Pulse Sensing (RPS) preferred.
• Leadership experience guiding graduate students on research projects.

Responsibilities

• 35%: perform experiments to secure resistive pulse signatures for the 20 amino acids using plastic in-plane nanopore sensors.
• 20%: build an integrated plastic-based system with an exopeptidase reactor and dual in-plane nanopore sensor to determine amino acid composition.
• 15%: fabricate in-plane nanopore sensors via modified injection molding with thermal fusion bonding and surface chemistries.
• 10%: mentor graduate students on RPS measurements and exopeptidase action on peptides.
• 10%: write peer-reviewed papers on RPS detection of single amino acids and on-line detection post-exopeptidase action.
• 5%: attend and present at weekly and national/international meetings; participate in outreach to the public and students.

Education

Ph.D. in Biomedical Engineering, Mechanical Engineering, or Chemistry

Job description

Position Overview

The Center of BioModular Multi-Scale Systems for Precision Medicine (CBMM) at the University of Kansas (College of Liberal Arts & Sciences and School of Engineering) is seeking qualified candidates for a post-doctoral fellow position to work on a nationally-funded project focused on developing nanotechnology for structural determinations of proteins. The candidate should have a Ph.D. in any of the following disciplines: biomedical engineering, mechanical engineering, or chemistry. Experiences in nanopore sensing both from a fabrication and operational perspective is preferred. A track record in Resistive Pulse Sensing (RPS), familiarity with machine learning, and protein/peptide chemistry is desirable. The person hired in this position will provide leadership to graduate students working on this project as well.

This position has funding for up to two years.

Job Description

• 35% - Using our plastic in-plane nanopore sensors using established techniques in the laboratory (injection molding and thermal fusion bonding), the PD will conduct experiments to secure resistive pulse signatures for the 20 amino acids.


• 20% - Build an integrated system in a plastic using injection molding that will consist of a solid-phase exopeptidase reactor coupled to the dual in-plane nanopore sensor to determine the amino acid composition of input peptides.


• 15% - Fabricate in-plane nanopore sensors via a modified injection molding process with an assembly process that uses thermal fusion bonding. This category also involves looking at different surface modification chemistries, including TRIS modification.


• 10% - Monitoring graduate students on the RPS measurements of single amino acid molecules and the action or exopeptidases when surface immobilized.


• 10% - Writing peer-reviewed papers covering topics on the detection and identification of single amino acids using RPS and the on-line detection of amino acids following exopeptidase action on peptides.


• 5% - Attend weekly group meetings and weekly sub-group meetings and make presentations at each of these meeting on an irregular basis (depends on scheduling). Also, make presentations on research work at national/international meetings at the discretion of the PI (Soper).


• 5% - Participate in outreach activities to the general public and school children on the basic concepts of protein/peptide/amino acid chemistry and RPS sensing. These activities are mandated by the funding source (NSF).

Required Qualifications

• Ph.D. in any of the following disciplines conferred at the time of appointment: biomedical engineering, mechanical engineering, or chemistry.

NOTE: To be appointed at the Postdoctoral Researcher title or equivalent title, it is necessary to have the Ph.D. in hand.

Appointments made without a diploma or certified transcript indicating an earned doctorate are conditional hires and are appointed on an acting basis not to exceed 6-months.

This position requires a formal degree in the cited discipline area(s) to ensure that candidates have advanced knowledge, analytical skills and professional competencies necessary to perform the duties of the position. The level of degree is commonly recognized as the standard qualification for similar roles in the public and private sector, ensuring that the university remains competitive with industry aligned practices, enhances collaboration with external partners, and supports the delivery of services and programs that meet professional and market-driven expectations.

Preferred Qualifications

• Experience in nanopore sensing both from a fabrication and operational perspective.


• Experience in working with Resistive Pulse Sensing (RPS).


• Knowledge of or experience with machine learning and protein/peptide chemistry as evidenced by application materials.

Contact Information to Applicants

Dr. Steven Soper, [e-mail]

Advertised Salary Range

$58,656

Anticipated Start Date

Friday January 1, 2027