Portfolio Operations Manager

1010 Genentech USA, Inc.; South San Francisco (CA); Hybrid; USD 142,000 - 264,000; Full time

Benefits offered by this job

Remote-friendly

Job summary

Genentech, a member of the Roche group, seeks a Portfolio Operations Manager to drive the CE enterprise portfolio. You will own intake, prioritization, governance, and the integrated view of capacity, dependencies, and milestones.

You will partner with CE Leadership, Regions, HEDs, RBO teams, and other stakeholders to ensure alignment with strategy and transparent portfolio decisions across competing priorities.

Qualifications

• Bachelor's degree required; MBA preferred.
• 8–10 years in portfolio, strategy, program management or operations.
• Experience facilitating senior leadership decisions with priorities.
• Strong analytical, synthesis, and governance capabilities.
• Ability to influence across a complex matrix organization.

Responsibilities

• Maintain the CE enterprise portfolio across initiatives, launches, and commitments.
• Own intake, evaluation, prioritization and sponsor alignment processes.
• Lead portfolio governance cadence and decision materials.
• Develop capacity, sequencing, and tradeoff recommendations.
• Provide executive synthesis and maintain milestone visibility.

Skills

Portfolio management experience

Executive communication skills

Strategic prioritization

Influence across organization

Travel willingness

Education

Bachelor's degree

MBA preferred

Job description

From the beginning, Genentech has been a team of highly dedicated, passionate individuals. We are a place where people are united around a single purpose and an ambitious vision. Together, we aspire to deliver ever better health outcomes for patients while lowering overall healthcare costs. Our goal is to compel the customer to act on behalf of their patients while showing great commitment to the rare disease community, whose support is key. Utilizing innovative methods to identify patients who may benefit from treatment, we must take a highly strategic approach to patient access while assisting patients and their caregivers to navigate the healthcare system.

POSITION SUMMARY

The Portfolio Operations Manager is responsible for the operating system that allows CE to evaluate, prioritize, sequence, and govern enterprise work as one portfolio. This role owns intake of proposed enterprise work, the prioritized CE portfolio roadmap, governance and decision cadence, and the integrated view of dependencies, duplication, capacity, and tradeoffs. The manager partners with CE Leadership, Enterprise Operations, Regions, HEDs, RBO teams, and other stakeholders to ensure the organization focuses resources on the work that matters most and can make transparent portfolio decisions when priorities compete.

SCOPE & KEY RESPONSIBILITIES

• Enterprise Portfolio Strategy & Roadmap Maintain the integrated CE enterprise portfolio across initiatives, launches, RBO work, and field-partner commitments. Translate CE strategy and leadership priorities into a prioritized portfolio roadmap. Create visibility to timing, sequencing, interdependencies, and major portfolio milestones. Identify duplication, overlap, and opportunities to combine or simplify work across the portfolio. Ensure portfolio views are current, decision-oriented, and useful to CE Leadership and operating teams.
• Intake, Evaluation & Prioritization Own the intake and evaluation process for proposed enterprise work. Establish clear criteria for strategic alignment, impact, urgency, effort, capacity, and enterprise value. Facilitate prioritization discussions and develop recommendations when demand exceeds available capacity. Ensure new work has a clear sponsor, problem statement, intended outcome, and required decision before entering the portfolio. Route approved work to the appropriate Enterprise Operations manager, lead, or enabling team for execution.
• Portfolio Governance & Decision Support Manage the portfolio governance cadence and prepare decision materials for CE Leadership and CELT as needed. Create transparent decision logs, escalation paths, and follow-through on portfolio choices. Provide concise synthesis of what is changing, why it matters, and what decisions or tradeoffs are required. Ensure governance focuses on material decisions, risks, and dependencies rather than routine status reporting. Partner with initiative and launch teams to maintain accurate portfolio status and milestone visibility.
• Capacity, Dependencies & RBO Integration Maintain an integrated view of enterprise capacity, demand, major dependencies, and resource constraints. Develop capacity, sequencing, and tradeoff recommendations across competing priorities. Integrate RBO work into the broader CE portfolio view so Regional and HED-supported commitments are visible and prioritized. Surface cross-portfolio risks and constraints early enough to enable leadership action. Partner with Enterprise Initiatives and Launch Operations to resolve conflicts and coordinate shared resources.
• Team Leadership & Portfolio Discipline Lead, coach, and develop Enterprise Operations Leads assigned to portfolio and RBO work. Set standards for portfolio data quality, governance materials, decision support, and milestone tracking. Allocate team capacity to the highest-priority portfolio needs and time-sensitive decisions. Build strong portfolio management capabilities, tools, and ways of working across the team. Contribute to common Enterprise Operations standards, talent practices, and continuous improvement.

KEY DELIVERABLES

• Prioritized CE enterprise portfolio roadmap
• Enterprise intake and evaluation process
• Portfolio governance calendar and decision materials
• Capacity, sequencing, and tradeoffs
• Integrated dependency, risk, and milestone view
• RBO portfolio and commitment visibility
• Executive portfolio dashboards and outcome reviews
• Portfolio standards, templates, and decision logs

MINDSET & CAPABILITIES

Enterprise thinker who prioritizes the whole over individual workstreams Strong judgment on value, urgency, effort, and tradeoffs Able to turn complexity into transparent portfolio choices Analytical and comfortable synthesizing imperfect information Strong facilitator of senior-level prioritization and decision discussions Skilled at influencing without formal authority Disciplined about governance without creating unnecessary bureaucracy Proactive in identifying capacity constraints, dependencies, and duplication Strong communication and executive synthesis capabilities Collaborative people leader and developer of talent Strong drive for results with an enterprise and customer mindset

REQUIRED QUALIFICATIONS

• Bachelor's degree required
• 8-10 years of pharmaceutical, biotechnology, consulting, commercial, portfolio, strategy, program management, and/or operations experience including leading, coaching or mentoring others strongly preferred
• Demonstrated experience with portfolio management, prioritization, governance, or resource planning
• Experience facilitating senior leadership decisions involving competing priorities and tradeoffs
• Strong analytical, synthesis, and project/program management capabilities
• Demonstrated ability to influence across a complex matrixed organization
• Strong communication and executive presentation skills
• Ability and willingness to travel as required for internal and external business meetings

PREFERRED QUALIFICATIONS

• Graduate-level degree (e.g., MBA or advanced life sciences degree)
• Prior commercial operations, portfolio management, strategy, or transformation experience
• Experience supporting large-scale field organizations, RBO, or enterprise planning processes

Location: This position can be based in SSF or Remote. Relocation benefits are not available.

The expected salary range for this position based on the primary location of CA is $142,200 - $264,200 USD Annual. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.

Benefits

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.

Who We Are

Genentech, a member of the Roche group and founder of the biotechnology industry, is dedicated to pursuing groundbreaking science to discover and develop medicines for people with serious and life-threatening diseases. To solve the world's most complex health challenges, we ask bigger questions that challenge our industry and the boundaries of science to transform society. Our transformational discoveries include the first targeted antibody for cancer and the first medicine for primary progressive multiple sclerosis. The next step is yours.

Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws. If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.