PhD: Stem Cell Organoid Models for Fibrosis Research

StrainX Biotech; United States; Remote; USD 23,000 - 37,000; Full time

Job summary

Biopatrika is seeking a highly motivated PhD candidate to advance 3D bone marrow and spleen organoid models at RWTH Aachen. You will lead experimental work to recapitulate cellular interactions and enable high‑throughput drug screening, aiming to uncover novel therapeutic targets for myelofibrosis.

The project blends stem cell biology, bioengineering, and computational analysis, with collaboration across disciplines and access to cutting‑edge technologies.

Qualifications

• An MSc in molecular biology, biotechnology, biomedical sciences, stem cell biology, bioengineering, or a related field.
• Hands-on experience with mammalian cell culture, preferably including primary cells or stem cells.
• Experience with 3D cultures, organoids, iPSCs, or tissue engineering is highly desirable.
• Solid molecular biology skills and experience with functional cellular assays.
• Ability to independently design experiments, optimize protocols, troubleshoot, and analyze results.
• Excellent communication and collaboration skills in interdisciplinary teams.

Responsibilities

• Develop and optimize advanced 3D bone marrow and spleen organoid models.
• Establish scalable platforms for high-throughput drug screening and validation.
• Investigate disease mechanisms and explore therapeutic strategies to reverse fibrosis.
• Apply single-cell and spatial multiomics to characterize interactions and responses.
• Collaborate with experts in stem cell biology, bioengineering, computational biology, and clinical hematology.

Skills

Mammalian cell culture

Organoid models

High-throughput screening

Multiomics technologies

Experimental design

Education

MSc in molecular biology

Tools

Single-cell analysis

Imaging analytics

3D culture techniques

Job description

Biopatrika is seeking a highly motivated PhD candidate to advance 3D bone marrow and spleen organoid models at RWTH Aachen. You will lead experimental work to recapitulate cellular interactions and enable high‑throughput drug screening, aiming to uncover novel therapeutic targets for myelofibrosis.

The project blends stem cell biology, bioengineering, and computational analysis, with collaboration across disciplines and access to cutting‑edge technologies.