PhD Genomics AI Benchmark Designer (Single-Cell)

Obsidian; San Diego (CA); On-site; USD 90,000 - 130,000; Full time

Job summary

Obsidian in San Diego seeks a Bioinformatics & Computational Single-Cell Genomics Expert to design graduate-level problems using real scientific software, run simulations, and guide AI models through complex workflows. You will craft challenging tasks around cell-type annotation, trajectory inference, and multi-omic integration while iterating on difficulty with cutting-edge models.

The role emphasizes hands-on coding with Scanpy, Scvelo, Squidpy, and Gudhi, and requires strong Python skills,

Qualifications

• Graduate-level training in a relevant STEM field (MS, PhD, or equivalent)
• Proven proficiency with at least one of the listed scientific software libraries
• Strong Python skills for problem setups, oracle functions, and validators
• Ability to work independently and refine problem designs based on feedback
• Comfortable with Linux/terminal environment and remote compute sandboxes
• Available for at least 15–20 hours per week

Responsibilities

• Create problems requiring skilled use of specialized scientific software
• Design problems around multi-step workflows and strategic questioning
• Test problems against state-of-the-art AI models and refine difficulty
• Interact with the evaluation loop to ensure target difficulty is met

Skills

Python

Graduate-level training

Independent work

Problem design

Scientific reasoning

Education

MS or PhD in a relevant STEM field

Tools

scanpy

scvelo

squidpy

gudhi

Job description

Obsidian in San Diego seeks a Bioinformatics & Computational Single-Cell Genomics Expert to design graduate-level problems using real scientific software, run simulations, and guide AI models through complex workflows. You will craft challenging tasks around cell-type annotation, trajectory inference, and multi-omic integration while iterating on difficulty with cutting-edge models.

The role emphasizes hands-on coding with Scanpy, Scvelo, Squidpy, and Gudhi, and requires strong Python skills,