Pediatrics - Neurology NRI (Instructor)

Baylor College of Medicine; Houston (TX); On-site; USD 85,000 - 120,000; Full time

Job summary

Baylor College of Medicine in Houston, TX, seeks a Pediatrics - Neurology NRI (Instructor) to lead genome editing efforts across iPSCs, neural models, and organoids, advancing translational research in neurodevelopmental disorders.

The successful candidate will design CRISPR-based strategies, generate edited cell lines, and collaborate with genetics, bioinformatics, and electrophysiology teams to integrate multi-omics data and pushes the boundaries of human disease modeling.

Qualifications

• Ph.D. in Molecular Biology, Genetics, Neuroscience, Bioengineering, or related
• 3+ years of hands-on genome editing, particularly CRISPR-based approaches
• Demonstrated mammalian cell culture experience, including stem cells (iPSCs preferred)
• Experience with cloning, vector design, and delivery systems (viral and non-viral)
• Strong molecular biology skills (PCR, qPCR, NGS, Western blotting)
• Experience with clonal isolation and edited-line validation
• Ability to design experiments independently and troubleshoot protocols
• Strong organizational, analytical, and communication skills

Responsibilities

• Design, develop, and optimize genome editing strategies using CRISPR/Cas systems
• Generate and validate genetically modified cell lines, including iPSCs
• Perform clonal selection, screening, and molecular validation
• Collaborate with cross-functional teams to integrate multi-omics data
• Maintain detailed records and contribute to publications and grants
• Stay current with new genome editing technologies and implement them

Skills

Genome editing

Mammalian cell culture

PCR/qPCR

NGS

Communication

Experimental design

Education

Ph.D. in Molecular Biology/Genetics/Neuroscience/Bioengineering

Tools

CRISPR/Cas systems

Cloning/Vector design

Delivery systems (viral & non-viral)

iPSCs

Organoid/3D culture

Job description

Job Title: Pediatrics - Neurology NRI (Instructor)

Division: Pediatrics

Work Arrangement:

Location: Houston, TX

Salary Range:

FLSA Status: Exempt

Work Schedule:

Summary

We are seeking a highly motivated and innovative Gene Editing Scientist to join amultidisciplinary team focused on developing cutting-edge human models of disease andadvancing translational applications in neurodevelopmental and neurodegenerativedisorders. The successful candidate will lead and execute genome engineering strategiesacross a range of platforms, including human induced pluripotent stem cells (iPSCs), 2Dhuman brain models, and organoids. This position offers a unique opportunity tocontribute to transformative discoveries at the intersection of gene editing and humandisease modeling.

Job Duties

• Design, develop, and optimize genome editing strategies using CRISPR/Cas systems (e.g., CRISPR-Cas9, base editing, prime editing)
• Generate and validate genetically modified cell lines, including iPSCs and differentiated neural cell types
• Perform clonal selection, screening, and molecular validation (PCR, sequencing, off-target analysis)
• Collaborate with cross-functional teams (genetics, bioinformatics, cell biology, electrophysiology) to integrate multi-omics and functional data
• Maintain detailed experimental records and contribute to publications, grant applications, and presentations
• Stay current with emerging genome editing technologies and implement innovative approaches
• Ensure compliance with institutional biosafety and regulatory guidelines

Minimum Qualifications

• Ph.D. in Molecular Biology, Genetics, Neuroscience, Bioengineering, or related
• field
• 3+ years of hands‑on experience in genome editing, particularly CRISPR-based
• approaches
• Demonstrated expertise in mammalian cell culture, including stem cells (iPSCs
• preferred)
• Experience with cloning, vector design, and delivery systems (viral and non‑viral)
• Strong background in molecular biology techniques (PCR, qPCR, NGS, Western
• blotting)
• Experience with clonal isolation and validation of edited lines
• Ability to design experiments independently and troubleshoot complex protocols
• Strong organizational, analytical, and communication skills

Preferred Qualifications

• Experience with advanced genome editing technologies (base editing, primeediting, epigenome editing)
• Familiarity with iPSC-derived models including organoid systems or 3D cell culturemodels
• Experience working with neurological or developmental disease models
• Knowledge of off-target analysis and genome‑wide screening approaches
• Experience with automation/robotics platforms for cell engineering workflows
• Bioinformatics skills related to sequence analysis

Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

Baylor College of Medicine fosters diversity among its students, trainees, faculty, and staff as a prerequisite to accomplishing our institutional mission and setting standards for excellence in training healthcare providers and biomedical scientists, promoting scientific innovation, and providing patient-centered care. Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.