Pathobiology Contractor

ACL Digital; San Mateo (CA); On-site; USD 90,000 - 120,000; Full time

Job summary

ACL Digital seeks a Research Associate III in Pathobiology for an 18-month contractor role onsite in Foster City. You will support drug discovery by optimizing IHC/CISH assays and developing tissue-based endpoints across oncology, fibrosis, virology, and inflammation.

The position requires a BS with extensive experience or an MS with significant relevant work; collaboration with internal groups and CROs will be essential to advance candidate targets and technologies.

Qualifications

• BS degree with 8+ years of relevant experience or an MS degree with 6+ years of experience.
• Direct participation in drug discovery and target identification/validation in oncology, fibrosis, inflammation, and virology.
• Experience with IHC method development, tissue handling, and data organization is required.

Responsibilities

• Optimize and/or validate antibody reagents for IHC and CISH.
• Develop tissue-based assays and contribute to method improvements in histological techniques.
• Plan, execute, and troubleshoot experiments supporting drug candidate projects; present findings to senior staff.
• Work cross-functionally with internal and external collaborators to identify novel targets and technologies.

Skills

IHC development

Tissue handling

Data management

Education

Bachelor's degree

MS degree

Tools

Microsoft Office

Image scanning software

Job description

Job Title: Research Associate - III/Pathobiology Contractor

Location: Onsite in Foster City

Schedule: M-F 9:00-17:00

Duration: 18 Months

Job Description

We are seeking a highly motivated, interactive, and creative individual to support drug discovery and development within Research. The successful candidate will be part of the Pathobiology Group which provides laboratory support throughout Client. He/she will work closely with internal client research groups as well as external collaborators to identify and validate novel drug targets in the areas of oncology, fibrosis, virology, and inflammation. Tissue-based endpoints will be used to investigate the efficacy and method of action and potential therapeutic targets. The successful candidate must be self-motivated and detail-oriented, exhibit excellent organizational and communication skills, demonstrate the ability to manage multiple priorities and work under tight timelines, thrive with a high degree of responsibility, and a proficient team-player. Specific duties will include optimization and/or validation of antibody reagents for IHC and CISH. He/she will have extensive experience in IHC, including method development, and will help with identification and implementation of process improvements in IHC and other histological techniques. He/she will work closely with internal client research groups as well as external collaborators to identify and validate novel drug targets in the areas of oncology, fibrosis, virology, and inflammation. He/she will be responsible for development of tissue-based assays and will have a background in biology or a related discipline and laboratory experience in human and animal tissue preparation and image scanning. Experience with multiplex IHC assays is a plus, but not necessary.

Development of infrastructure, tissue collections, technology and novel methodology will be implemented as needed through a combination of in-house efforts and the use of relevant CROs or other external expertise. The successful candidate must be able to independently plan, execute, and troubleshoot decisional experiments that support the initiation and/or advancement of drug candidate projects. The candidate will work cross-functionally within the organization to achieve goals, present research findings and recommendations to senior staff, and identify new technologies that may increase throughput or enhance our understanding of disease mechanisms.

Applicants should have a BS degree and 8+ years of relevant experience or an MS degree with 6+ years of experience.

Experience

The candidate’s work history should demonstrate the direct participation in drug discovery and target identification/validation in oncology, fibrosis, inflammation, and virology research by IHC and other histological techniques. Necessary technical skills include IHC method-development protocols, tissue handling, and organized data entry. Proficiency with Microsoft Office is required. Applicants should be able to troubleshoot independently, use both strategic and tactical thinking effectively, and show curiosity-driven engagement in scientific problems. The successful candidate needs to be able to manage more than one project at any given time, to work successfully in a cross-functional and highly collaborative team environment, and to communicate clearly to a variety of audiences in both speech and writing.