On-DNA Synthesis Chemist for Platform Chemistry (Contract)

YOH Services LLC; Cambridge (MA); On-site; USD 94,000 - 103,000; Full time

Benefits offered by this job

Medical, Prescription, Dental & Vision

Health Savings Account (HSA)

Life & Disability Insurance

MetLife Voluntary Benefits

Employee Assistance Program (EAP)

401K Retirement Savings Plan

Direct Deposit & weekly epayroll

Referral Bonus Programs

Certification and training

Job summary

Yoh Life Sciences in Cambridge, MA, is hiring an Organic Chemist / Platform Chemistry Scientist for the Encoded Technologies team. This onsite, contract role focuses on hands-on synthesis and DNA-encoded library chemistry to drive early drug discovery.

The ideal candidate will independently plan and execute synthetic experiments, troubleshoot complex reactions, and collaborate across a multidisciplinary team in a fast-paced lab environment.

Qualifications

• PhD in Organic Chemistry, Medicinal Chemistry, Chemical Biology, or closely related discipline with substantial synthetic organic chemistry research experience.
• Strong hands-on experience in synthetic organic chemistry and small-molecule synthesis.
• Experience with reaction development, reaction optimization, and troubleshooting.
• Ability to independently plan, execute, analyze, and document laboratory experiments.
• Strong understanding of organic reaction mechanisms and synthetic strategy.
• Ability to work effectively in a collaborative, fast-paced laboratory environment.
• Attention to detail and commitment to high-quality scientific work.

Responsibilities

• Synthesize on-DNA compounds to support binder confirmation and drug discovery projects within established timelines.
• Develop, evaluate, and optimize DNA-compatible organic reactions for use in DNA-encoded library production.
• Design and execute synthetic chemistry experiments, including reaction screening and optimization.
• Troubleshoot reaction performance and use experimental data to guide subsequent chemistry.
• Analyze, interpret, document, and communicate experimental results clearly.
• Maintain high standards of laboratory safety, data quality, and documentation.
• Collaborate with scientists across chemistry and other drug discovery functions.
• Manage multiple experiments and priorities while delivering high-quality results.

Skills

Organic chemistry

Medicinal chemistry

Chemical biology

Synthesis

Reaction development

Plan and execute experiments

Data interpretation

Detail-oriented

Education

PhD in Organic Chemistry or related field

Tools

LC-MS

HPLC

NMR

Job description

Yoh Life Sciences in Cambridge, MA, is hiring an Organic Chemist / Platform Chemistry Scientist for the Encoded Technologies team. This onsite, contract role focuses on hands-on synthesis and DNA-encoded library chemistry to drive early drug discovery.

The ideal candidate will independently plan and execute synthetic experiments, troubleshoot complex reactions, and collaborate across a multidisciplinary team in a fast-paced lab environment.