Oligonucleotide Synthesis & Purification Co-op

Scorpion Therapeutics; United States; On-site; USD 28,000 - 34,000; Full time

Job summary

Wave Life Sciences is seeking a motivated co-op student in Lexington, Massachusetts. The role provides exposure to oligonucleotide synthesis, purification, and analysis, with hands-on training on lab techniques and instrumentation.

Organic chemistry or Biochemistry lab experience is preferred, and strong PPE adherence is essential. Responsibilities include reagent prep, purification, oligo synthesis, TFF operations, and data analysis using ELN and Excel.

Qualifications

• Organic chemistry or Biochemistry lab experience preferred.
• Willingness to learn and operate lab instrumentation.

Responsibilities

• Prepare reagents and column packing for oligo synthesis.
• Prepare buffers, clean and sanitize equipment.
• Purify oligonucleotides.
• Prepare oligonucleotide synthesis and handle amidites.
• Quantitate oligos using spectrophotometers.
• Perform Tangential Flow Filtration (TFF) on purified oligos.
• Operate automated synthesizers, purifiers, TFF systems, and lyophilizers.
• Analyze samples by UPLC and LC-MS.
• Use Excel for data processing, analysis and interpretation.
• Document experiments in ELN and maintain batch records.
• Maintain inventory.

Skills

Lab safety (PPE)

Communication

Tools

Oligonucleotide synthesizers

Purifiers

TFF systems

Lyophilizers

LC-MS

UPLC

ELN

Job description

Wave Life Sciences is seeking a motivated co-op student in Lexington, Massachusetts. The role provides exposure to oligonucleotide synthesis, purification, and analysis, with hands-on training on lab techniques and instrumentation.

Organic chemistry or Biochemistry lab experience is preferred, and strong PPE adherence is essential. Responsibilities include reagent prep, purification, oligo synthesis, TFF operations, and data analysis using ELN and Excel.