Oligonucleotide Method Development & Validation

LabRulez; Lancaster (Lancaster County); Ibrido; USD 90.000 - 120.000; Tempo pieno

Vantaggi offerti da questo lavoro

Medical coverage

Dental and vision coverage

401(k) with company match

Paid vacation and holidays

Descrizione del lavoro

Eurofins USA BioPharma Services, in Lancaster, PA, seeks an Oligonucleotide Scientist to develop, validate, and execute analytical methods for oligonucleotide API testing, with a primary focus on HPLC/UHPLC and LC‑MS workflows in a GMP environment.

The role requires authoring methods, protocols and reports, ensuring data integrity, mentoring junior staff, and managing client projects while maintaining regulatory compliance. Full-time, on-site, with travel as needed.

Competenze

• BS or MS in Analytical Chemistry or related field with relevant experience.
• Experience with oligonucleotides in a GMP environment.
• Strong chromatography and MS knowledge; method development and validation.

Mansioni

• Develop, validate, and execute analytical methods for oligonucleotide testing.
• Perform HPLC/UHPLC, GC, UV/Vis, and dissolution analyses.
• Read and interpret procedures; conduct analytical investigations.
• Train and mentor junior staff; manage projects with clients.
• Ensure GMP compliance and data integrity in all activities.

Conoscenze

Communication

Independent work

Teamwork

Attention to detail

Formazione

BS in Analytical Chemistry

MS in Analytical Chemistry

Strumenti

HPLC

UHPLC

Mass spectrometry

GC

Dissolution

Descrizione del lavoro

Scientific and Research Fellow, Analytical chemist, Molecular spectroscopy UV-Vis, RAMAN, FTIR, Liquid chromatography, Gas chromatography, Liquid chromatography-mass spectrometry

Eurofins Scientific is an international life sciences company, providing a unique range of analytical testing services to clients across multiple industries, to make life and our environment safer, healthier and more sustainable. From the food you eat, to the water you drink, to the medicines you rely on, Eurofins works with the biggest companies in the world to ensure the products they supply are safe, their ingredients are authentic and labelling is accurate. Eurofins believes it is a global leader in food, environmental, pharmaceutical and cosmetics products testing and in agroscience CRO services. It is also one of the global independent market leaders in certain testing and laboratory services for genomics, discovery pharmacology, forensics, CDMO, advanced material sciences and in the support of clinical studies.

In over 35 years, Eurofins has grown from one laboratory in Nantes, France to 61,000 staff across a decentralised and entrepreneurial network of ca. 900 laboratories in 61 countries. Eurofins companies offer a portfolio of over 200,000 analytical methods to evaluate the safety, identity, composition, authenticity, origin, traceability and purity of biological substances and products.

In 2025, Eurofins generated total revenues of EUR 7.296 billion, and has been among the best performing stocks in Europe over the past 20 years.

Job Description

Applicants MUST have authorization to work in the U.S. indefinitely without restriction orsponsorship.

Job Summary:

The Oligonucleotide Scientist is responsible for developing, optimizing, validating, and executing analytical methods to support oligonucleotide API, drug substance, and drug product testing. The role supports pharmaceutical clients throughout various stages of the drug pipeline but does not support or include synthesis/manufacturing of oligonucleotides. The role focuses primarily on HPLC/UHPLC and mass spectrometry (e.g., LC‑MS, LC‑MS/MS) for identity, purity/impurity profiling, quantitation, and stability-indicating assessments. The scientist will author methods, protocols and reports, ensure data integrity and compliance within GxP environments, and provide technical leadership for routine testing and investigations and mentoring of junior staff.Additional tasks/skills will include:

• Performing a large variety of analytical tasks for the validation of analytical methods used in the testing of drug products and raw materials by means of various procedures including HPLC, GC, UV/Vis, and dissolution.
• Reading, understanding, and interpreting diverse analytical procedures.
• Conducting analytical investigations.
• Troubleshoot instrumentation and communicate with vendors when required.
• Train and mentor junior staff in laboratory procedures.
• Manage and discuss projects with clients.
• Applies GMP in all areas of responsibility, as appropriate.

Qualifications

The Ideal Candidate would possess:

• Excellent communication (oral and written) and attention to detail.
• Ability to work independently and as part of a team, self-motivation, adaptability, and a positive attitude
• Ability to learn new techniques, perform multiple tasks simultaneously, keep accurate records, follow instructions, and comply with company policies

Minimum Qualifications:

• At least a BS or MS degree in Analytical Chemistry or related scientific discipline
  • BS and 4+ years, MS and 2+ years, or PhD and 1+ year of relevant industry experience
• Experience performing analytical testing with oligonucleotides in a GMP-regulated environment
• Technical Expertise: Strong theoretical and practical knowledge of chromatography (HPLC, UHPLC, IEX, SEC) and mass spectrometry, including method development, validation, and routine testing
• Regulatory Knowledge: Familiarity with ICH guidelines and GxP regulatory standards
• Background should be primarily in analytical testing or analytical method development; candidates with primarily synthesis or process chemistry experience without analytical/QC responsibilities will not be considered
• Authorization to work in the U.S. indefinitely without restriction or sponsorship

Additional Information

Working schedule will beFull-Time, First Shift, Mon-Fri, 8am-4pm.Candidatescurrently living within a commutable distance of Lancaster, PAare encouraged to apply. 25% travel may be required. This position isNOTremote.

What we Offer:

• Excellent full time benefits including comprehensive medical coverage, dental, and vision options
• Life and disability insurance
• 401(k) with company match
• Paid vacation and holidays

Eurofins USA BioPharma Services is a Disabled and Veteran Equal Employment Opportunity employer.