MS&T Associate Director, Oligonucleotide Manufacturing

Arrowhead Pharmaceuticals, Inc.; Madison (WI); On-site; USD 180,000 - 240,000; Full time

Job summary

Arrowhead Pharmaceuticals, Inc. is seeking an Associate Director, MS&T to lead process transfer, scale-up, and tech transfer activities for internal oligo manufacturing.

You will manage cross-functional teams, ensure GMP compliance, and drive continuous improvements in manufacturing efficiency and quality. Located in Madison, WI, this role requires extensive experience in GMP drug substance development and regulatory alignment, with a focus on transferring processes from development to

Qualifications

• PhD/MS/BS with extensive GMP drug substance development experience.
• Experience in scale-up of chemistry processes, especially oligonucleotides.
• Knowledge of GMP guidelines, regulatory requirements (FDA/ICH).
• Proven in technology transfer and process validation activities.

Responsibilities

• Lead process engineering, tech transfer, and validation teams for internal oligo manufacturing.
• Oversee GMP document generation and change control processes.
• Manage direct and indirect reports to ensure timely delivery of high-quality work.
• Collaborate with cross-functional teams to enable seamless process transfer.
• Mentor team members and drive career development and knowledge sharing.

Skills

GMP compliance

Technology transfer

Scale-up experience

Project management

Analytical method familiarity

Cross-functional collaboration

Communication skills

Safety culture

Education

PhD in Organic Chemistry

MS in Organic Chemistry

BS in Chemistry

Tools

HPLC-MS

UV spectroscopy

NMR

Job description

Arrowhead Pharmaceuticals, Inc. is seeking an Associate Director, MS&T to lead process transfer, scale-up, and tech transfer activities for internal oligo manufacturing.

You will manage cross-functional teams, ensure GMP compliance, and drive continuous improvements in manufacturing efficiency and quality. Located in Madison, WI, this role requires extensive experience in GMP drug substance development and regulatory alignment, with a focus on transferring processes from development to