MES Engineer

Biopharma Careers; Jaffrey (NH); On-site; USD 116,000 - 175,000; Full time

Benefits offered by this job

Health insurance

Paid time off (PTO)

Retirement contributions

Job summary

MilliporeSigma in Jaffrey, NH seeks a MES Engineer to support and improve Siemens Opcenter MES, providing day-to-day user support, configuration updates, and coordination with IT and cross-functional teams to align MES with site operations, quality, and compliance requirements.

The role collaborates with site SMEs, Operations, Quality, Validation, Automation, IT, and global digital teams, including potential future MES expansion and change-management activities.

Qualifications

• Bachelor’s degree in STEM, engineering, computer science, or related field.
• 5+ years of manufacturing experience.
• 2+ years supporting manufacturing, OT, MES, or related digital systems in production.
• Basic knowledge of manufacturing process support and system troubleshooting.
• Knowledge of Siemens Opcenter MES configuration and integrations.

Responsibilities

• Perform MES modeling and configuration changes to address operational needs.
• Resolve workflow, reporting, and integration issues in MES with cross-functional teams.
• Work with IT to support issues impacting Production uptime.
• Support equipment and enterprise system interfaces by monitoring data flow.
• Lead change management activities for MES maintenance with cross-functional support.
• Perform change assessments and support qualification and validation activities.
• Create and maintain technical documentation aligned with GAMP and SDLC.
• Ensure MES activities comply with GxP, data integrity, and quality requirements.
• Partner with Operations, Quality, Validation, Automation, IT for continuous improvement.

Skills

Manufacturing experience

MES support

Cross-functional collaboration

Analytical troubleshooting

Education

Bachelor’s degree in STEM

Tools

Siemens Opcenter MES

SQL queries

SAP Business Objects

OPC UA connectivity

Job description

Work Your Magic with us! Start your next chapter and join MilliporeSigma.

Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.

This role does not offer sponsorship for work authorization. External applicants must be eligible to work in the US.

Your Role

The MES Engineer supports the effective use and continuous improvement of Siemens Opcenter MES at the Jaffrey site. This role provides day-to-day user and operational support, troubleshooting, business-facing configuration updates, and coordination with IT and cross-functional teams to help ensure MES supports site operations, quality, and compliance requirements. The role works closely with site SMEs, Operations, Quality, Validation, Automation, IT, and global digital teams, and may also support future MES expansion activities.

Key Responsibilities

• Perform MES modeling and configuration changes and enhancements to address operational needs, improve user experience, and align system use with site processes and user requirements.
• Resolve workflow, reporting, integration, and usage issues in MES, in collaboration Opcenter SME and cross-functional teams.
• Work with IT to support resolution to issues affecting Production uptime as needed.
• Support equipment and enterprise system interfaces by monitoring data flow, troubleshooting issues, and coordinating enhancements with cross-functional teams.
• Lead change management activities for all MES maintenance and improvement initiatives for existing deployments, with support from the cross-functional team.
• Perform change assessments and support qualification and validation activities for system updates, fixes, and enhancements
• Create and maintain technical documentation aligned with GAMP, SDLC, and site procedures
• Ensure MES-related activities comply with GxP, data integrity, EHS, and quality requirements
• Partner with Operations, Quality, Validation, Automation, IT, and other teams to support continuous improvement and effective site use of MES

Who You Are

Minimum Qualifications

• Bachelor’s degree in STEM, engineering, computer science, technical management, or a related field
• 5+ years of manufacturing experience
• 2+ years of experience supporting manufacturing, OT, MES, or related digital systems in a production environment
• Basic knowledge of manufacturing process support and system troubleshooting
• Knowledge of or willingness to learn Siemens Opcenter MES configuration, including modeling objects, business rules, expressions, user queries, and integrations

Preferred Qualifications

• Working Knowledge of ISO & FDA regulations (such as ISO 9001, ISO 13485 or 21 CFR 820, 210 & 211).
• Knowledge of SQL queries, SAP Business Objects, or related reporting and data tools
• Familiarity with equipment integration and interface support, including OPC UA or similar connectivity
• Understanding of GxP-regulated environments and GAMP requirements
• Experience supporting system improvements, upgrades, or small enhancement activities
• Strong analytical, problem-solving, and communication skills

Pay Range for this position: $116,400 - $174,600

The offer range represents the anticipated low and high end of the base pay compensation for this position. The actual compensation offered will be determined by factors such as location, level of experience, education, skills, and other job-related factors. Position may be eligible for sales or performance-based bonuses.

Benefits offered by the Company include health insurance, paid time off (PTO), retirement contributions, and other perquisites.

For more information click here .

What we offer

We are curious minds that come from a broad range of backgrounds, perspectives, and life experiences. We believe that this variety drives excellence and innovation, strengthening our ability to lead in science and technology. We are committed to creating access and opportunities for all to develop and grow at your own pace. Join us in building a culture of inclusion and belonging that impacts millions and empowers everyone to work their magic and champion human progress!