Medicinal Chemistry Lead — AI-Powered Drug Design

Isomorphic Labs; London (KY); Hybrid; USD 190,000 - 270,000; Full time

Job summary

Isomorphic Labs is building AI-driven drug discovery to design medicines faster and more effectively. We are hiring Medicinal Drug Design Leads to provide scientific leadership and hands-on chemistry work within an interdisciplinary team.

You will steer medicinal chemistry strategy across programs, collaborate with AI/ML platform teams, and work with CROs and collaborators to deliver milestones while mentoring junior scientists in a culture of inclusion and continuous learning.

Qualifications

• PhD in Medicinal Chemistry or related field, or equivalent industrial experience.
• 5+ years in medicinal chemistry in biotech/pharma/CRO settings.
• Proven track record leading medicinal chemistry on drug discovery projects (hit to lead).
• Experience with structure-based drug design problems.
• Excellent strategic thinking, problem-solving, and decision-making in drug discovery.
• Experience managing CRO resources.
• Strong publications, patents, and presentations.
• Passion for AI/ML to transform drug discovery.
• Excellent communication, written and verbal, in cross-functional teams.
• Growth mindset and eagerness to learn new concepts and techniques.

Responsibilities

• Invent new medicines and drive drug discovery programs to value inflection points.
• Collaborate cross-functionally to deliver data-driven scientific solutions to complex problems.
• Provide strategic input and technical direction to AI/ML platform teams.
• Represent the company externally with collaborators and CROs.
• Effectively manage CRO resources and monitor KPIs to maintain delivery.
• Prepare detailed scientific proposals and reports to support new programs.
• Embrace and champion our culture of inclusion and continuous professional development.

Skills

Medicinal Chemistry

Drug Discovery

CRO management

Structure-based design

Communication skills

Education

PhD in Medicinal Chemistry or related field

Job description

Isomorphic Labs is building AI-driven drug discovery to design medicines faster and more effectively. We are hiring Medicinal Drug Design Leads to provide scientific leadership and hands-on chemistry work within an interdisciplinary team.

You will steer medicinal chemistry strategy across programs, collaborate with AI/ML platform teams, and work with CROs and collaborators to deliver milestones while mentoring junior scientists in a culture of inclusion and continuous learning.