Mass Spectrometry Scientist

Hamlyn Williams; Los Angeles (CA); On-site; USD 100,000 - 120,000; Full time

Job summary

An innovative biotech firm in Los Angeles is seeking a detail-oriented Mass Spectrometry Scientist to lead analytical characterization of bioconjugate therapeutics. This role involves overseeing mass spec analyses, developing internal workflows, and collaborating with cross-functional teams. You will play a crucial part in understanding conjugation efficiency and pharmacokinetics within a fast-paced, startup environment. If you're passionate about advancing therapeutic solutions and thrive in a dynamic setting, this is the perfect opportunity for you to make a significant impact in the life sciences sector.

Qualifications

• 2-5 years of experience with mass spectrometry in an industry setting.
• Hands-on experience in LC-MS/MS for protein analysis and bioanalytical PK quantification.

Responsibilities

• Lead mass spec-based QC of therapeutic conjugates using top-down proteomics.
• Analyze in vivo plasma and tissue samples via LC-MS/MS in partnership with CROs.

Skills

Mass Spectrometry

Analytical Chemistry

Biochemistry

LC-MS/MS

Data Analysis

Conjugation Chemistry

Education

M.S. or Ph.D. in Analytical Chemistry

Pharmaceutical Sciences

Tools

Xcalibur

MassLynx

Skyline

Job description

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This range is provided by Hamlyn Williams. Your actual pay will be based on your skills and experience — talk with your recruiter to learn more.

Base pay range

$100,000.00/yr - $120,000.00/yr

Senior Vice President - Head of Life Sciences at Hamlyn Williams

Mass Spectrometry Scientist (Associate Scientist or Scientist I)

Position Type: Full-Time

Start Date: Immediate

Hamlyn Williams is partnered with a biotech in Los Angeles who is seeking a detail-oriented and scientifically rigorous Mass Spectrometry Scientist to oversee and execute analytical characterization of their growing pipeline of bioconjugate and antibody/peptide/oligo-based therapeutics. This role will be integral to their understanding of conjugation efficiency, in vivo pharmacokinetics, and molecular identity across platforms.

You will initially interface closely with external CROs and instrumentation partners to drive top-down mass spec analyses and in vivo PK quantification, later helping establish internal mass spec workflows as we build on-site capabilities. This is a unique opportunity to own analytical development in a fast-paced, platform-driven startup environment.

Key Responsibilities

• Lead or support regular mass spec-based QC of therapeutic conjugates using top-down proteomics, including intact mass confirmation and drug-to-antibody ratio (DAR) assessments.
• Perform and interpret bottom-up peptide mapping in collaboration with chemists and protein engineers.
• Analyze in vivo plasma and tissue samples to detect and quantify peptide or oligonucleotide species via LC-MS/MS, in partnership with CROs.
• Develop and standardize data processing and reporting pipelines, ensuring analytical rigor and reproducibility.
• Serve as a technical liaison with external mass spec providers and CROs, ensuring timely delivery, quality control, and method alignment.
• Contribute to the future build-out of internal mass spec capabilities—including equipment selection, workflow design, and SOP development.
• Collaborate cross-functionally with chemistry, biology, in vivo, and CMC teams to ensure integrated data flow for decision-making.

Basic Qualifications

• M.S. or Ph.D. in Analytical Chemistry, Biochemistry, Pharmaceutical Sciences, or related discipline.
• 2-5 years of experience with mass spectrometry, preferably in an industry setting focused on biologics, ADC, or oligo.
• Hands-on experience in LC-MS/MS, especially for intact protein analysis, peptide mapping, and bioanalytical PK quantification.
• Familiarity with conjugation chemistry and its analytical implications.
• Proven ability to oversee external CROs and manage mass spec workflows under time-sensitive timelines.

Preferred Qualifications

• Experience with oligonucleotide / peptide mass spec or detection of oligonucleotide / peptide in plasma/tissue matrices.
• Experience with bioconjugation, protein engineering, or organic synthesis.
• Proficiency in data analysis tools such as Xcalibur, MassLynx, Skyline, or vendor-specific platforms.
• Familiarity with early-stage CMC analytical needs, including assay qualification.
• Knowledge of bioanalytical regulatory standards (e.g., GLP-like expectations for non-GLP studies).
• Comfortable navigating a startup environment with evolving infrastructure and high ownership expectations.

Seniority level

Associate

Employment type

Full-time

Job function

Science

Industries

Biotechnology Research and Pharmaceutical Manufacturing