MariTide, OSA and PIE Program Execution Lead, Senior Director

Biopharma Careers; United States; Hybrid; USD 180,000 - 243,000; Full time

Benefits offered by this job

Retirement plan

Medical, dental, vision coverage

Life and disability insurance

Flexible spending accounts

Discretionary bonus program

Stock-based incentives

Generous time-off plans

Flexible work model

Job summary

Amgen is seeking a seasoned Program Execution Lead, Senior Director, to shape and drive enterprise integrated execution across MariTide lifecycle expansion initiatives, including OSA and PIE. You will align global priorities with cross-functional teams, ensuring timely delivery of milestones that maximize patient and business impact.

You will partner with senior leaders to manage risks, dependencies, and opportunities, driving continuous improvement and effective governance across functions and

Qualifications

• Doctorate, Master’s, or Bachelor’s in a relevant field and 5–10+ years in biopharmaceutical execution.
• Experience leading cross-functional programs from development to commercialization.
• Strong analytical and governance facilitation skills.

Responsibilities

• Lead enterprise portfolio integration and strategic influence across OSA and PIE initiatives.
• Shape the integrated program plan and critical timelines for launch readiness.
• Drive cross-functional alignment across Development, Medical, Regulatory, Commercial and Operations.
• Develop recommendations and enable senior leadership decision-making at key milestones.
• Identify risks, dependencies, and trade-offs to optimize execution and value.

Skills

Cross-functional leadership

Portfolio management

Strategic execution

Program management

Executive communication

Education

Doctorate degree

Master’s degree

Bachelor’s degree

Tools

Project management tools

Job description

Career Category

Project Management

Job Description

Join Amgen’s Mission of Serving Patients

At Amgen, if you feel like you’re part of something bigger, it’s because you are. Our shared mission, to serve patients living with serious illnesses, drives all that we do.

Since 1980, we’ve helped pioneer the world of biotech in our fight against the world’s toughest diseases. With our focus on four therapeutic areas –Oncology, Inflammation, General Medicine, and Rare Disease– we reach millions of patients each year. Amgen is advancing a broad and deep pipeline of medicines to treat cancer, heart disease, inflammatory conditions, rare diseases, and obesity and obesity-related conditions. As a member of the Amgen team, you’ll help make a lasting impact on the lives of patients as we research, manufacture, and deliver innovative medicines to help people live longer, fuller happier lives.

Our award-winning culture is collaborative, innovative, and science based. If you have a passion for challenges and the opportunities that lay within them, you’ll thrive as part of the Amgen team. Join us and transform the lives of patients while transforming your career.

MariTide, OSA and PIE Program Execution Lead, Senior Director

What you will do

Let’s do this. Let’s change the world. In this vital role under the direction of the Chronic Weight Management Global Indication Lead, this role responsible for shaping and driving enterprise integrated execution across MariTide lifecycle expansion initiatives, including Obstructive Sleep Apnea (OSA), Patient Impact Expansion (PIE), and future obesity franchise opportunities. The role serves as the integrator across obesity Obstructive Sleep Apnea (OSA) and Patient Impact Expansion (PIE), being accountable for enabling cross-functional decision‑making, influencing portfolio prioritization, and driving successful delivery of key milestones that maximize patient and business impact.

Key Responsibilities:

• Lead enterprise portfolio integration and strategic influence across the cross-functional execution of the OSA indication and PIE initiatives, ensuring alignment across development, medical, regulatory, commercial, and operations functions.
• Shape and operationalize the integrated program plan and critical timelines, driving accountability, visibility, and delivery against key milestones.
• Drive execution excellence across Global Development, Medical, Commercial, Regulatory, Market Access, and Operations functions to ensure successful execution of interconnected portfolio initiatives, proactively identifying risks, dependencies, and trade-offs to enable timely, decision-ready outcomes.
• Translate strategy into actionable plans, ensuring clear linkage between global objectives and operational effectiveness to support launch readiness and lifecycle management.
• Lead cross-functional alignment and decision-making, serving as a central integrator to ensure clarity, speed, and coordinated execution and prioritization across stakeholders.
• Own integrated program processes, including development of recommendations, strategic options, and decision-enablement materials for senior leadership and governance forums, enabling efficient, data-driven decisions at key program milestones.
• Influence prioritization of activities and resources, aligning execution against highest‑value opportunities and portfolio objectives.
• Embed continuous improvement and cross-program learning into execution to enhance team effectiveness, agility, and speed to patient.
• Partner with senior leadership to identify and mitigate enterprise risks, dependencies, and operational challenges impacting program delivery.
• Lead cross‑functional planning processes and ensure linkage between global strategy, business priorities, and operational execution.
• Anticipate emerging portfolio risks, competitive developments, and strategic opportunities and provide recommendations to senior leadership regarding priorities and execution strategies.
• Drive collaboration across functions and geographies to support efficient execution and alignment with broader enterprise objectives.

What we expect of you

We are all different, yet we all use our unique contributions to serve patients. The professional we seek is a collaborative leader with these qualifications.

Basic Qualifications:

• Doctorate degree and 5 years of biopharmaceutical commercialization, global strategy execution, or program management experience
• Master’s degree and 8 years of biopharmaceutical commercialization, global strategy execution, or program management experience
• Bachelor’s degree and 10 years of biopharmaceutical commercialization, global strategy execution, or program management experience

Preferred Qualifications:

• Consulting experience with a leading management consulting firm is highly preferred.
• Demonstrated experience solving complex business problems in a consulting environment, including stakeholder management, data analysis, and strategic recommendations.
• Strong analytical and problem‑solving skills with experience managing multiple stakeholders and leading cross‑functional initiatives.
• Proventrack recordof leading complex, cross‑functional programs through key development and commercialization milestones
• Strong executive presence with experience supporting senior governance and decision‑making forums
• Demonstrated ability to influence without authority and drive alignment across diverse, global stakeholders

Core Competencies:

• Strategic Execution,Operational Leadershipand Commercialization
• Cross‑Functional Influence & Alignment
• Program & Project Management Excellence
• Executive Communication & Decision Enablement
• Risk Management & Problem Solving
• Agility and Continuous Improvement

What you can expect of us

As we work to develop treatments that take care of others, we also work to care for your professional and personal growth and well‑being. From our competitive benefits to our collaborative culture, we’ll support your journey every step of the way.

• A comprehensive employee benefits package, including a Retirement and Savings Plan with generous company contributions, group medical, dental and vision coverage, life and disability insurance, and flexible spending accounts
• A discretionary annual bonus program, or for field sales representatives, a sales‑based incentive plan
• Stock‑based long‑term incentives
• Award‑winning time‑off plans
• Flexible work models where possible. Refer to the Work Location Type in the job posting to see if this applies.

In any materials you submit, you may redact or remove age-identifying information such as age, date of birth, or dates of school attendance or graduation. You will not be penalized for redacting or removing this information.

Sponsorship

Sponsorship for this role is not guaranteed.

As an organization dedicated to improving the quality of life for people around the world, Amgen fosters an inclusive environment of diverse, ethical, committed and highly accomplished people who respect each other and live the Amgen values to continue advancing science to serve patients. Together, we compete in the fight against serious disease.

Amgen is an Equal Opportunity employer and will consider all qualified applicants for employment without regard to race, color, religion, sex, sexual orientation, gender identity, national origin, protected veteran status, disability status, or any other basis protected by applicable law.

We will ensure that individuals with disabilities are provided reasonable accommodation to participate in the job application or interview process, to perform essential job functions, and to receive other benefits and privileges of employment. Please contact us to request accommodation.

Salary Range

179,965.40USD -243,482.60USD