Manufacturing Supervisor

Global Life Science Hub; Chicago (IL); On-site; USD 70,000 - 90,000; Full time

Job summary

A leading biopharmaceutical company in Chicago is seeking a Manufacturing Supervisor for 3rd shift operations. The role involves overseeing biologics production processes, ensuring compliance with cGMP regulations, and managing a team. Ideal candidates have a Bachelor's or Master's in relevant fields and experience in biopharma manufacturing. This full-time position requires a commitment to working overnight shifts.

Qualifications

• 5+ years of biopharma manufacturing experience, or 2+ years with a Master's degree.
• Strong supervisory or team lead experience preferred.
• Experience in upstream or downstream biologics manufacturing.

Responsibilities

• Supervise day-to-day manufacturing operations.
• Monitor and troubleshoot production processes and equipment.
• Train and manage direct reports for compliance.

Skills

Biopharma manufacturing experience

Supervisory experience

GMP documentation

Team management

Education

Bachelor’s in Engineering or Life Sciences

Master’s in related field

Job description

Overview

Manufacturing Supervisor (Drug Substance) – 3rd Shift

Chicago, IL | Full-Time | On-Site

We are hiring a Manufacturing Supervisor (Drug Substance) to join our growing biopharmaceutical manufacturing operations in Chicago, IL. This is a hands-on supervisory role on 3rd shift (10:00 PM – 6:00 AM), responsible for overseeing biologics production processes in a cGMP-regulated environment.

Responsibilities

• Supervise and support day-to-day manufacturing operations, including media/buffer preparation
• Chromatography column setup and operation
• Aseptic final filtration of intermediates and drug substances
• Monitor and troubleshoot production processes and equipment (PLC/HMI, pH, conductivity, spectroscopy)
• Ensure accurate and timely completion of batch records, deviations, change controls, and CAPAs
• Train, mentor, and manage direct reports to ensure adherence to cGMP and safety standards
• Drive shift engagement, performance reviews, and cross-shift communication
• Coordinate with QA, PD, Validation, and Supply Chain to support production readiness and continuous improvement

Qualifications

• Bachelor’s in Engineering, Life Sciences, or related field with 5+ years of biopharma manufacturing experience, or Master’s with 2+ years of experience, or 5–10 years of equivalent industry experience
• Prior supervisory or team lead experience strongly preferred
• Strong background in upstream or downstream biologics manufacturing
• Proficiency in GMP documentation, batch records, and compliance
• Comfortable working overnight (10 PM – 6 AM, 3rd shift) and ensuring shift handovers