Machine Learning Scientist II

Revolution Medicines; United States; On-site; USD 182,000 - 214,000; Full time

Benefits offered by this job

Competitive equity

Strong benefits

Learning opportunities

Job summary

Revolution Medicines is seeking a Machine Learning Scientist II to accelerate drug discovery through advanced analytics and AI. This hands-on role develops predictive models transforming chemical and biological data into actionable insights for research teams.

Collaborate with data scientists, medicinal chemists, and biologists to translate questions into analyses, validate models, and integrate analytics into discovery pipelines. Strong ML foundations and teamwork required.

Qualifications

• PhD in machine learning, computational biology, computational chemistry, computer science, statistics, bioinformatics, or related field; or MS with relevant industry experience.
• 2–5 years of relevant experience applying ML to scientific datasets; doctoral research may count.
• Experience developing, validating, and evaluating predictive or classification models.
• Strong Python programming and scientific computing libraries (NumPy, Pandas, SciPy).
• Hands-on familiarity with ML frameworks (PyTorch, TensorFlow, scikit-learn).
• Experience with data visualization and working with noisy experimental data.
• Ability to communicate technical work clearly and collaborate with cross-functional teams.

Responsibilities

• Develop, implement, and evaluate ML models to answer drug discovery questions.
• Collaborate with chemistry and biology teams to translate scientific questions into analyses.
• Create reusable workflows and contribute to data-driven discovery pipelines.
• Document methods, code, results, and assumptions for reproducibility.
• Communicate findings and implications to non-technical stakeholders.

Skills

Python programming

Machine learning

Data analysis

Cross-functional collaboration

Communication

Education

PhD in ML/comp bio/comp chem/CS/stats/bioinformatics

MS with relevant industry experience

Tools

PyTorch

TensorFlow

scikit-learn

RDKit

OpenEye

Job description

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor - all in service of patients.

The Opportunity:

• We are seeking a Machine Learning Scientist II to help accelerate drug discovery through advanced analytics and artificial intelligence. This hands‑on individual contributor will develop and apply predictive models and analytical methods that transform complex biological and chemical datasets into actionable insights for research teams.
• The Machine Learning Scientist II will work at the interface of data science, chemistry, and biology to support target discovery, compound optimization, phenotypic screening, and translational research. The role is well suited to a scientist who brings strong technical foundations in machine learning, curiosity about drug discovery, and a collaborative approach to solving real‑world scientific problems.
• Working with senior data scientists and experimental collaborators, the successful candidate will contribute analyses, models, and reusable workflows to a data‑driven discovery ecosystem where data, analytics, and experimentation continuously inform one another.
• Develop, implement, and evaluate machine-learning models that support drug discovery questions, including compound activity, selectivity, developability, target engagement, and phenotypic screening outcomes.
• Perform exploratory data analysis and quality assessment on chemical, biological, imaging, and phenotypic datasets.
• Prepare and integrate heterogeneous datasets, including chemical structure and screening data, structural biology outputs, molecular simulation outputs, and high-content imaging or morphological profiling data.
• Apply appropriate modeling approaches, including supervised learning, deep learning, graph-based methods, and ensemble methods, under the guidance of project and functional leads.
• Use sound validation strategies to assess model performance, robustness, applicability, and limitations.
• Collaborate with data engineering and machine‑learning engineering partners to support reproducible workflows and integration of analytical outputs into discovery pipelines.
• Partner with medicinal chemists, biologists, and other research scientists to translate scientific questions into computational analyses and communicate results clearly.
• Document methods, code, results, and key assumptions in a manner that supports reproducibility and knowledge sharing.

Required Skills, Experience and Education:

• Ph.D. in machine learning, computational biology, computational chemistry, computer science, statistics, bioinformatics, or a related quantitative field; or a M.S. degree with relevant industry experience.
• Typically 2-5 years of relevant experience applying machine learning, data science, or advanced analytics to scientific datasets; relevant doctoral research may be considered.
• Demonstrated experience developing, validating, and evaluating predictive or classification models.
• Strong Python programming skills and experience with scientific computing libraries such as NumPy, Pandas, and SciPy.
• Hands‑on familiarity with machine‑learning frameworks such as PyTorch, TensorFlow, and/or scikit‑learn.
• Experience with data visualization, exploratory data analysis, and working with noisy or incomplete experimental datasets.
• Ability to communicate technical work clearly and collaborate effectively with cross‑functional scientific partners.

Preferred Skills:

• Experience in biotechnology, pharmaceutical, healthcare, or drug discovery environments.
• Experience with phenotypic screening, high-content imaging, Cell Painting, morphological profiling, or computer vision for microscopy images.
• Familiarity with representation learning, self‑supervised learning, embedding generation, dimensionality reduction, clustering, or phenotype discovery.
• Familiarity with cheminformatics or molecular modeling tools, such as RDKit or OpenEye.
• Experience with multi‑omics data analysis, cloud computing environments, MLOps, or scalable model deployment.
• Working knowledge of cell biology, drug discovery workflows, assay development, microscopy, experimental design, or biological interpretation of machine‑learning results.

The base pay salary range for this full‑time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job‑related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact [e-mail].

Base Pay Salary Range

$182,000 - $214,000 USD