LNP Formulation Scientist I (Contract)

IT Engagements; California (MO); On-site; USD 70,000 - 100,000; Full time

Job summary

IT Engagements is seeking a motivated SD_Scientist I to join the Formulation team in San Diego, CA. In this hands-on lab role, you will develop and optimize lipid nanoparticle formulations for nucleic acid delivery, working closely with senior scientists.

The ideal candidate will have 2+ years in LNP formulation, strong data analysis skills, and proficiency with Excel; DoE experience and knowledge of DLS/Zeta potential/RiboGreen assays are preferred.

Qualifications

• Bachelor's degree in Chemistry, Biochemistry, Chemical Engineering or related field with 4+ years biopharma experience, OR a Master's with 1+ years experience.
• Minimum of 2 years hands-on LNP formulation and encapsulation of nucleic acids (mRNA, siRNA, or DNA).
• Experience with LNP characterization methods including DLS, Zeta potential, and Ribogreen assays.

Responsibilities

• Execute and optimize formulation and characterization of lipid nanoparticles (LNPs) or tLNPs encapsulating nucleic acids for in vitro and in vivo studies.
• Implement Design of Experiments (DoE) based screening campaigns to optimize LNP compositions and processing parameters.
• Collaborate cross-functionally with internal teams to fulfill formulation requests.
• Support early-stage formulation development and downstream processing activities including cryoprotection, scale-up, and stability studies.
• Maintain detailed records of formulation activities and results.
• Analyze, interpret, and present experimental data to the formulation team.
• Contribute to routine lab management including inventory, buffer prep, and autoclaving.

Skills

LNP formulation

Nucleic acid encapsulation

DLS

Zeta potential

RiboGreen assays

MS Excel

DoE-based screening

Statistical data analysis

Communication

Education

Bachelor's degree in Chemistry/ Biochemistry/ Chemical Engineering

Master's degree with 1+ years industry experience

Tools

JMP

Prism

Job description

IT Engagements is seeking a motivated SD_Scientist I to join the Formulation team in San Diego, CA. In this hands-on lab role, you will develop and optimize lipid nanoparticle formulations for nucleic acid delivery, working closely with senior scientists.

The ideal candidate will have 2+ years in LNP formulation, strong data analysis skills, and proficiency with Excel; DoE experience and knowledge of DLS/Zeta potential/RiboGreen assays are preferred.