Liver Disease & HBV Research Opportunities

Washington University in St. Louis; St. Louis (MO); On-site; USD 42,000 - 70,000; Full time

Job summary

Washington University in St. Louis is seeking motivated researchers and technicians to join a cutting-edge HBV, SARS-CoV-2 and liver biology program.

The role involves work in a laboratory setting within the Schwartz Laboratory, contributing to organoid platforms and regenerative medicine approaches, with emphasis on hepatic cell biology and viral pathogenesis. Preferred candidates have experience in mouse handling, liver-related biology, primary cell culture, histology, immunofluorescence,

Qualifications

• Bachelor's degree or combination of education and/or experience may substitute for minimum education.
• Experience with mouse handling, liver/gi biology experience, histology, immunofluorescence, imaging-based analysis, and molecular virology are preferred.

Education

Bachelor's degree

Tools

Job description

Position Summary

Location

SAINT LOUIS, MO 63110

Scheduled Hours

40

Position Summary

The Schwartz Laboratory in the Division of Gastroenterology, Department of Medicine, at Washington University School of Medicine in St. Louis is seeking motivated and creative technicians, scientists and postdocs to join our interdisciplinary research program investigating: the biology of hepatitis B virus (HBV) and the mechanisms that allow the virus to establish and maintain chronic infection; how SARS-CoV-2 and other respiratory pathogens interact with human tissue; working at the forefront of human liver tissue engineering and regenerative medicine; the fundamental cell biology of the liver; how hepatocytes, cholangiocytes, stromal and endothelial cells establish and maintain liver architecture, respond to injury, and regenerate; and how metabolic dysfunction, cellular communication, and genetic alterations contributing to liver disease and cancer.

Our long-term goals are: to understand the complex interactions between HBV and its host that drive viral persistence and to use these insights to identify new strategies toward a functional cure for chronic hepatitis B, which remains a major global health challenge and an important cause of liver-related morbidity and mortality; to establish a multi-organ organoid and stem cell-derived platform that contributes to our understanding of viral pathogenesis and host immune responses; to develop GMP-grade, hypoimmunogenic bioartificial liver for transplantation; to determine how the different liver cells respond to injury and their impacts on regeneration and fibrosis; and to uncover fundamental mechanisms of disease and identifying new opportunities for therapeutic intervention.

We are seeking individuals with prior experience in molecular biology, biochemistry, genetics and/or cell biology.

Projects and requirements will vary depending on candidate background and experience.

Job Description

Primary Duties & Responsibilities:

Working Conditions:

This position works in a laboratory environment with potential exposure to biological and chemical hazards. The individual must be physically able to wear protective equipment and to provide standard care to research animals.

Salary Range:

Base pay is commensurate with experience.

The above statements are intended to describe the general nature and level of work performed by people assigned to this classification. They are not intended to be construed as an exhaustive list of all job duties performed by the personnel so classified. Management reserves the right to revise or amend duties at any time.

Education:

Required Qualifications

Bachelor’s degree or combination of education and/or experience may substitute for minimum education.

Certifications /Professional Licenses :

No specific certification/professional license is required for this position.

Work Experience:

No specific work experience is required for this position.

Skills:

Not Applicable

Driver's License:

A driver's license is not required for this position.

Preferred Qualifications:

More About This Job

• Experience with mouse handling, husbandry, and/or survival surgery.
• Experience in liver, gastrointestinal, or developmental biology research.
• Experience with primary hepatocyte or other primary cell culture.
• Experience in histology, immunofluorescence, or imaging-based analysis.
• Experience in bioengineering.
• Experience in molecular virology.
• Demonstrated analytical, reasoning and problem-solving skills.
• Ability to analyze and interpret statistical data and to communicate data in a clear, concise manner.
• Adept at using Microsoft Office Suite and the ability to use software packages to analyze data.
  
  

Education:

Preferred Qualifications

No additional education unless stated elsewhere in the job posting.

Certifications/Professional Licenses:

No additional certification/professional licenses unless stated elsewhere in the job posting.

Work Experience:

No additional work experience unless stated elsewhere in the job posting.

Skills:

Communication, Laboratory Research, Organizing, Recordkeeping, Working Independently

Grade

00

Questions

For frequently asked questions about the application process, please refer to our External Applicant FAQ.

Accommodation

If you are unable to use our online application system and would like an accommodation, please email [e-mail] or call the dedicated accommodation inquiry number at 314-935-1149 and leave a voicemail with the nature of your request.

All qualified individuals must be able to perform the essential functions of the position satisfactorily and, if requested, reasonable accommodations will be made to enable employees with disabilities to perform the essential functions of their job, absent undue hardship.

Pre-Employment Screening

All external candidates receiving an offer for employment will be required to submit to pre-employment screening for this position. The screenings will include criminal background check and, as applicable for the position, other background checks, drug screen, an employment and education or licensure/certification verification, physical examination, certain vaccinations and/or governmental registry checks. All offers are contingent upon successful completion of required screening.

Benefits Statement

Washington University in St. Louis is committed to providing a comprehensive and competitive benefits package to our employees. Benefits eligibility is subject to employment status, full-time equivalent (FTE) workload, and weekly standard hours. Please visit our website at https://hr.wustl.edu/benefits/ to view a summary of benefits.

EEO Statement

Washington University in St. Louis is committed to the principles and practices of equal employment opportunity. It is the University’s policy to provide equal opportunity and access to persons in all job titles without regard to race, ethnicity or shared ancestry, color, national origin, citizenship (where prohibited by federal law), age, religion, sex, sexual orientation, gender identity or expression, disability, protected veteran status, or genetic information. As a federal contractor, the university maintains affirmative action programs to implement its equal employment opportunity policy for individuals with disabilities and protected veterans, in accordance with Section 503 of the Rehabilitation Act of 1973, as amended, and the Vietnam Era Veterans’ Readjustment Assistance Act of 1974 (VEVRAA), as amended.