Lead Research Scientist — Cryo-EM & Vaccine Design

FHLB Des Moines; Seattle (WA); On-site; USD 99,444 - 122,124; Full time

Job summary

University of Washington in Seattle is seeking a Research Scientist/Engineer 4 for leading projects in single-particle cryo-electron microscopy and X-ray crystallography of viral glycoproteins. The role focuses on immunogen design, protein subunit vaccines, and data-driven strategy across collaborations.

The candidate will perform structure-based design, binding assays, and high-throughput structural studies, while guiding staff and contributing to publications.

Qualifications

• Master's Degree in Biochemistry or related field.
• Four years of experience in cryo-EM, virology assays, protein expression in mammalian cells, and purification.

Responsibilities

• Lead structure-based immunogen design for protein subunits and vaccines.
• Characterize antigenicity using ELISAs, SPR, and biolayer interferometry.
• Perform high-throughput cryo-EM studies and X-ray crystallography.
• Design and execute virology assays and analyze data to steer research strategy.
• Provide guidance to staff, students, and postdocs and contribute to manuscripts.

Skills

Cryo-EM

Protein expression

Immunogen design

Biochemistry

Biophysics

Machine learning

Education

Master's degree in Biochemistry

Tools

Beckman Biomek

Job description

University of Washington in Seattle is seeking a Research Scientist/Engineer 4 for leading projects in single-particle cryo-electron microscopy and X-ray crystallography of viral glycoproteins. The role focuses on immunogen design, protein subunit vaccines, and data-driven strategy across collaborations.

The candidate will perform structure-based design, binding assays, and high-throughput structural studies, while guiding staff and contributing to publications.