Research Scientist/Engr 4

FHLB Des Moines; Seattle (WA); On-site; USD 99,444 - 122,124; Full time

Job summary

University of Washington in Seattle is seeking a Research Scientist/Engineer 4 for leading projects in single-particle cryo-electron microscopy and X-ray crystallography of viral glycoproteins. The role focuses on immunogen design, protein subunit vaccines, and data-driven strategy across collaborations.

The candidate will perform structure-based design, binding assays, and high-throughput structural studies, while guiding staff and contributing to publications.

Qualifications

• Master's Degree in Biochemistry or related field.
• Four years of experience in cryo-EM, virology assays, protein expression in mammalian cells, and purification.

Responsibilities

• Lead structure-based immunogen design for protein subunits and vaccines.
• Characterize antigenicity using ELISAs, SPR, and biolayer interferometry.
• Perform high-throughput cryo-EM studies and X-ray crystallography.
• Design and execute virology assays and analyze data to steer research strategy.
• Provide guidance to staff, students, and postdocs and contribute to manuscripts.

Skills

Cryo-EM

Protein expression

Immunogen design

Biochemistry

Biophysics

Machine learning

Education

Master's degree in Biochemistry

Tools

Beckman Biomek

Job description

## Research Scientist/Engr 4Applylocations: Seattle, WAtime type: Full timeposted on: Posted 13 Days Agojob requisition id: REQ-0000129345**Job Description****Field of research:**Single particle cryo-electron microscopy and X-ray crystallization of viral glycoproteins, immunogen design, virology, biochemistry and biophysics.**Purpose of the Research Project(s):**The goal of our research is to develop vaccines and therapeutics targeting human pathogens.**Duties and Responsibilities:**20% Structure-based and machine-learning immunogen design for protein subunit and mRNA vaccines based on viral surface glycoproteins (construct design, recombinant expression in mammalian cells, purification, and stability assays),20% Characterize protein antigenicity (binding assays using ELISAs, SPR and biolayer interferometry to evaluate binding kinetics and affinity of antibodies or designed proteins),15% Perform structural studies (high-throughput cryo-electron microscopy of subunit vaccines as well as of complexes between viral glycoproteins and monoclonal and polyclonal antibodies as well as X-ray crystallography), 10% Design and execution of virology assays,10% Analysis of the data to help determining the research strategy,10% Lead projects and/or major project tasks,10% Interactions with collaborators within our network and writing of manuscripts for publication5% Provide guidance and direction to project staff, students and postdocs**Requirements:**Master's Degree in Biochemistry or related field and four years 4 years of experience in related field like: Cryo-electron microscopy, virology assays (pseudotyped virus generation, cellular entry and neutralization assays), protein expression in mammalian cells and purificationEquivalent education and/or experience may substitute for minimum qualifications except when there are legal requirements, such as a license, certification, and/or registration.**Desire:**Expertise in protein and vaccine design, experience in high throughput automation using Beckman Biomek.**Compensation, Benefits and Position Details****Pay Range Minimum:**$99,444.00 annual**Pay Range Maximum:**$122,124.00 annual**Other Compensation:**-**Benefits:**For information about benefits for this position, visit https://www.washington.edu/jobs/benefits-for-uw-staff/**Shift:**First Shift (United States of America)**Temporary or Regular?**This is a regular position**FTE (Full-Time Equivalent):**100.00%