Lead Purification Scientist - Kilo-Lab Chromatography

Biopharma Careers; Boston (MA); On-site; USD 138,000 - 207,000; Full time

Job summary

Vertex Pharmaceuticals seeks a highly experienced Principal Scientist to join the VMC Kilo Lab, leading preparative chromatography method development and scale-up for drug substance purification in a cGMP setting. The role spans R&D and manufacturing, including large-scale HPLC, SFC, LIMS/EMPOWER data systems, and cross-functional collaboration with Process Chemistry, Quality, and Manufacturing.

The candidate should have deep expertise in RP, NP, IEX, SEC, and scale-up strategies, with a strong

Qualifications

• Ph.D. in Analytical/Organic/Medicinal/Chemical Engineering or related field preferred.
• 10+ years of hands-on R&D and cGMP experience in drug substance development and purification.
• Demonstrated leadership in cross-functional teams and ability to mentor junior staff.

Responsibilities

• Lead development, optimization, and scale-up of preparative chromatography (HPLC, SFC) from analytical to kilogram scale.
• Troubleshoot complex purification campaigns and develop robust solutions.
• Build and maintain large-scale chromatography platforms and qualifying infrastructure.

Skills

Preparative chromatography

HPLC

SFC

IP-RP_HPLC

AEX/CEX

SEC

Mentoring staff

cGMP

Analytical development

Education

PhD preferred

Bachelor/Master considered

Tools

Empower

OpenLab

HPLC systems

SFC equipment

Job description

Vertex Pharmaceuticals seeks a highly experienced Principal Scientist to join the VMC Kilo Lab, leading preparative chromatography method development and scale-up for drug substance purification in a cGMP setting. The role spans R&D and manufacturing, including large-scale HPLC, SFC, LIMS/EMPOWER data systems, and cross-functional collaboration with Process Chemistry, Quality, and Manufacturing.

The candidate should have deep expertise in RP, NP, IEX, SEC, and scale-up strategies, with a strong