Lead Pharmacology Scientist, RNA Therapeutics & PK/PD

Nosis Bio; Alameda (CA); On-site; USD 130,000 - 170,000; Full time

Job summary

Nosis Bio is seeking a Principal Scientist in Pharmacology to lead molecular biology strategy and execution for studies characterizing pharmacokinetics, pharmacodynamics, biodistribution, and target engagement of RNA therapeutics.

This hands-on leadership role will own studies from design through data interpretation, driving development decisions in collaboration with discovery biology, chemistry and data science.

Qualifications

• PhD in Molecular Biology, Biochemistry, Genetics, Pharmacology, or related field.
• Experience with quantitative PCR methods and molecular assay development.
• Ability to design pharmacology studies and integrate molecular results with cross-functional datasets.
• On-site work in Alameda, California.

Responsibilities

• Design and lead quantitative molecular biology studies for PK, PD, biodistribution, target engagement, and gene expression assessments.
• Develop, optimize, qualify, and oversee workflows for RNA and DNA extraction, cDNA synthesis, RT-qPCR, qPCR, and ddPCR across programs.
• Establish robust sample-processing workflows for cells, tissues, and biofluids, including homogenization, lysis, cleanup, quantification, and RNase-free handling.
• Translate program questions into study strategies with appropriate controls, replication, timelines, and sample requirements.
• Analyze and integrate complex datasets, including relative and absolute quantification and assay performance metrics.
• Lead troubleshooting and root-cause investigations for assay and instrument performance; implement improvements.
• Establish and maintain SOPs, assay qualification summaries, data analysis templates, and training materials.
• Ensure accurate, real-time documentation in ELN with protocols, raw data, deviations, and conclusions.
• Coordinate cross-functionally so sample generation, handling, analysis, and reporting align with study objectives.
• Present data with clear context, controls, conclusions, and recommendations to guide plans.

Skills

Quantitative PCR

Molecular biology

Assay development

Data analysis

Cross-functional leadership

Education

PhD in Molecular Biology or related field

Tools

RT-qPCR

ddPCR

RNA/DNA extraction workflows

Job description

Nosis Bio is seeking a Principal Scientist in Pharmacology to lead molecular biology strategy and execution for studies characterizing pharmacokinetics, pharmacodynamics, biodistribution, and target engagement of RNA therapeutics.

This hands-on leadership role will own studies from design through data interpretation, driving development decisions in collaboration with discovery biology, chemistry and data science.