Lead Peptide Discovery Scientist/AD — Early Biotech

Mixtalent; San Francisco (CA); On-site; USD 210,000 - 260,000; Full time

Job summary

Mixtalent is seeking a Principal Scientist/Associate Director to lead peptide discovery programs in a stealth biotech focused on metabolic bone disease in the San Francisco Bay Area. You will oversee peptide discovery campaigns, collaborate with CROs, and drive optimization efforts to advance candidates toward the clinic.

The role requires a PhD with 5+ years in peptide drug discovery, deep experience in potency, stability, and biophysical properties, and a track record in peptide medicinal

Qualifications

• Ph.D. in chemistry or biochemistry with 5+ years in peptide drug discovery in biotech.
• Deep experience managing peptide discovery workflows including potency and stability optimization.
• Experience with non-canonical modifications to native peptides to improve potency and properties.
• Experience in medicinal chemistry related to peptides and non-canonical modifications.
• Experience engineering peptides for improved oral bioavailability.
• Ability to manage multiple projects with CRO partners.
• Program leadership experience in biotech or pharma.
• Ability to work in a virtual environment with external partners.
• Independent self-starter with strong organizational and communication skills.

Responsibilities

• Work with partner CROs on design and implementation of peptide discovery and optimization campaigns
• Collaborate with biology leads to design and implement peptide hit screening funnels
• Devise lead optimization strategies to identify drug candidates
• Interrogate strategies to improve oral bioavailability

Skills

Peptide discovery

Project management

Lead optimization

Oral bioavailability

Medicinal chemistry

Structural analysis

Independent self-starter

Education

PhD in chemistry/biochemistry

Tools

Structural analysis tools

Job description

Mixtalent is seeking a Principal Scientist/Associate Director to lead peptide discovery programs in a stealth biotech focused on metabolic bone disease in the San Francisco Bay Area. You will oversee peptide discovery campaigns, collaborate with CROs, and drive optimization efforts to advance candidates toward the clinic.

The role requires a PhD with 5+ years in peptide drug discovery, deep experience in potency, stability, and biophysical properties, and a track record in peptide medicinal