Peptide Discovery Sr Scientist/Associate Director

Mixtalent; San Francisco (CA); On-site; USD 210,000 - 260,000; Full time

Job summary

Mixtalent is seeking a Principal Scientist/Associate Director to lead peptide discovery programs in a stealth biotech focused on metabolic bone disease in the San Francisco Bay Area. You will oversee peptide discovery campaigns, collaborate with CROs, and drive optimization efforts to advance candidates toward the clinic.

The role requires a PhD with 5+ years in peptide drug discovery, deep experience in potency, stability, and biophysical properties, and a track record in peptide medicinal

Qualifications

• Ph.D. in chemistry or biochemistry with 5+ years in peptide drug discovery in biotech.
• Deep experience managing peptide discovery workflows including potency and stability optimization.
• Experience with non-canonical modifications to native peptides to improve potency and properties.
• Experience in medicinal chemistry related to peptides and non-canonical modifications.
• Experience engineering peptides for improved oral bioavailability.
• Ability to manage multiple projects with CRO partners.
• Program leadership experience in biotech or pharma.
• Ability to work in a virtual environment with external partners.
• Independent self-starter with strong organizational and communication skills.

Responsibilities

• Work with partner CROs on design and implementation of peptide discovery and optimization campaigns
• Collaborate with biology leads to design and implement peptide hit screening funnels
• Devise lead optimization strategies to identify drug candidates
• Interrogate strategies to improve oral bioavailability

Skills

Peptide discovery

Project management

Lead optimization

Oral bioavailability

Medicinal chemistry

Structural analysis

Independent self-starter

Education

PhD in chemistry/biochemistry

Tools

Structural analysis tools

Job description

A stealth mode start-up biotech with a metabolic bone disease focus in the San Francisco/Bay Area is adding to their team. This is a well-funded biotech that's looking to build their team with a Peptide Discovery Principal Scientist/Associate Director (leveling/title flexible, dependent on experience) who is looking to help drive programs forward with experience optimization peptides and managing projects by working with CRO's.

Description

Work with Research Leadership and partner CROs on design and implementation of the peptide drug pipeline. Lead programs in a fast-paced early biotech environment and manage the peptide drug discovery workflows including but not limited to peptide discovery campaigns, platform development, optimization, synthesis and characterization.

Key Responsibilities

• Work with partner CROs on design and implementation of peptide discovery and optimization campaigns
• Collaborate with biology leads to design and implement peptide hit screening funnels
• Devise lead optimization strategies to identify drug candidates
• Interrogate various strategies to improve oral bioavailability

Requirements

• Ph.D. in chemistry, biochemistry or related fields with 5 years of experience in peptide drug discovery in the biotech industry
• Deep experience and understanding of peptide discovery workflows including discovery and optimization of potency, stability, and other biophysical properties required of a clinical drug candidate
• Experience in structural analysis tools and the ability to propose non-canonical modifications to native peptide sequences to improve potency and other desired biophysical qualities.
• Experience in medicinal chemistry related to peptides and non-canonical modifications
• Experience in engineering peptides for increased oral bioavailability
• Ability to manage multiple projects with CRO partners
• Program leadership experience in biotech or pharma
• Ability to work with flexibility in a virtual environment with multiple external partners
• Independent self-starter with strong organizational and communication skills