Lead Oligonucleotide Analytics Scientist

Deepgenomics; Cambridge (MA); On-site; USD 150,000 - 180,000; Full time

Benefits offered by this job

Stock ownership

Health, vision, and dental

Flexible work environment

Learning & development budget

Parental leave top-up

Job summary

Deep Genomics in Cambridge, MA is seeking a highly skilled analytical scientist to lead oligonucleotide characterization and formulation for in vitro and in vivo studies. The role includes ensuring identity and purity of oligos from external CROs and internal metabolism experiments, plus building an analytics lab strategy and sample tracking.

The ideal candidate has a PhD in analytical or related fields with HPLC and mass spectrometry expertise, strong collaboration and communication skills, and

Qualifications

• PhD or MS with strong analytical chemistry background in oligonucleotides.
• Experience with HPLC and mass spectrometry.
• Experience in oligonucleotide analytics and formulation.

Responsibilities

• Maintain efficient workflows for analytical characterization of DG oligos at CROs.
• Develop and implement a future plan for LCMS system installation for oligonucleotide analysis.
• Act as DG KOL for characterization of oligonucleotides (identity, purity, stability).
• Develop analytical methods for the future LCMS system to characterize research oligonucleotide samples.
• Generate Certificate of Analysis reports from such data.
• Perform formulation processes to provide research samples for in vitro and in vivo experiments including endotoxin analysis.
• Develop and maintain a sample tracking system for the compounds that come into Deep Genomics at Cambridge.
• Future responsibilities may include bioanalysis of PK samples.

Skills

Communication skills

Collaboration

Oligonucleotide techniques

Process design

Oligonucleotide therapeutics

In vitro / in vivo ADAR siRNA ASO

Bioanalysis & GxP

Education

PhD in analytical, pharmaceutical sciences, or bio-organic chemistry including expertise in HPLC and mass spectrometry

MS in similar fields with +5 years experience

Job description

Deep Genomics in Cambridge, MA is seeking a highly skilled analytical scientist to lead oligonucleotide characterization and formulation for in vitro and in vivo studies. The role includes ensuring identity and purity of oligos from external CROs and internal metabolism experiments, plus building an analytics lab strategy and sample tracking.

The ideal candidate has a PhD in analytical or related fields with HPLC and mass spectrometry expertise, strong collaboration and communication skills, and