Lead Manufacturing Scientist, CAB - Dean's Office

UCLA Health; Los Angeles (CA); Presencial; USD 91.000 - 194.000; Jornada completa

Descripción de la vacante

UCLA Health seeks a Lead Manufacturing Scientist for the Center for Advanced Biotherapies (CAB) to oversee GMP manufacturing and QC testing of gene and cell therapy products. The role requires advanced tissue culture expertise and strong management of projects and personnel.

Expect collaboration with physicians and sponsors, with a focus on cost effectiveness and innovation. The position involves supervising manufacturing staff, ensuring SOP adherence, and driving process improvements for

Formación

• Bachelor of Science or Master of Science or Ph.D. in Biology, Chemistry, or related field and a minimum of 2 years of manufacturing experience in GMP setting.
• Knowledge and practical experience in aseptic technique/tissue culture.
• Understanding of GMP requirements and regulations. Previous experience directly involved with federal regulations regarding GLP and GMP.
• Knowledge of SOPs and Quality Control requirements in a GMP laboratory setting.
• Work independently, with emphasis on following SOPs.
• Ability to wear protective clothing for extended periods.
• Ability to work flexible hours, including short-notice shifts.
• Ability to serve as a resource for procedural troubleshooting.
• Work under exposure to zoonotic diseases, anesthetic agents, and chemicals.
• Strong interpersonal communication with physicians, staff, administration & sponsors.
• Experience managing complex projects.
• Advanced knowledge of cell culture, bioreactor operation, scale-up, filtration, and centrifugation.
• Expert in flow cytometry, protein, mRNA, DNA characterization.
• Excellent record-keeping and documentation practices.
• Ability to work independently and collaboratively across departments.
• Ability to handle confidential information with discretion.
• Strong decision-making under ambiguous criteria.
• Ability to manage multiple projects concurrently.
• Ability to attend off-site meetings.
• Ability to prepare concise administrative reports and SOPs.
• Working knowledge of medical/scientific terminology for protocol work.
• Demonstrated records management and complex filing systems.
• Proficiency with computers, spreadsheets, databases, and word processing.

Responsabilidades

• Manufacture clinical grade gene and cellular therapy products under GMP.
• Quality control testing to ensure product quality.
• Oversee manufacturing associates and project management across multiple projects.
• Lead development, scale-up, and process improvements for cell culture and bioprocessing.
• Collaborate with departments to ensure compliance and innovation.

Conocimientos

Tissue culture

GMP culture

Project management

Flow cytometry

Cell culture

Bioreactor operation

Scale-up

Documentation

Data analysis

Confidential info

Educación

BS/MS/PhD in Biology or Chemistry

Herramientas

Flow cytometer

Centrifugation equipment

Ultracentrifuge

Descripción del empleo

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Work Schedule

Monday - Friday, 8:00 AM - 5:00 PM

Posted Date

10/07/2026

Salary Range: $90720.00 - 194040.00 Annually

Employment Type

Duration

Indefinite

Job #

33606

Primary Duties and Responsibilities

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Under the supervision of the Manufacturing Manager of the Center for Advanced Biotherapies (CAB), the CAB Lead Manufacturing Scientist is responsible for the manufacturing of human gene and cell therapy products under Good Manufacturing Practices (GMP), quality control testing of these products to ensure that the products meet the required quality, oversee other manufacturing associates and overall management of all projects. The purpose of the CAB is to manufacture clinical grade gene and cellular therapy products for novel patient treatments in clinical trials, and to perform scholarly research and development when appropriate. These objectives are to be met within the limits of resources available with an emphasis on cost effectiveness and innovation.

The Lead Manufacturing Scientist must have advanced tissue culture expertise, preferably including human cell line and stem cell culture. This position requires experience with GMP-grade culture and formulation of various human cell types, including peripheral blood mononuclear cells (PBMCs), T cells, dendritic cells, mesenchymal stromal cells, human embryonic stem cells, and induced pluripotent stem cells. In addition, the candidate must possess strong project and personnel management skills and have experience conducting and managing quality control testing.

Annual Salary Range: $90,720.00 - $194,040.00

Job Qualifications

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Required:

• Bachelor of Science or Master of Science or Ph.D. Degree in Biology, Chemistry, or related field and a minimum of 2 years of manufacturing experience in GMP setting.
• Knowledge and practical experience in aseptic technique/tissue culture.
• Understanding of GMP requirements and regulations. Previous experience directly involved with federal regulations regarding GLP and GMP.
• Knowledge of Standard Operating Procedures and Quality Control requirements in a GMP laboratory setting.
• Work independently, with emphasis on the ability to closely follow SOPs.
• Ability to wear protective clothing for extended periods of time including: gowns, coveralls, gloves, masks, face shields, goggles, sleeves and head covers.
• Ability to work flexible hours, various hours on short notice (including covering staff shortages and holiday shifts); determine workload priorities for completion of job assignments in a timely manner to meet critical deadlines
• Ability to serve as a resource for complex procedure or equipment troubleshooting in areas of expertise, and/or solicits same as necessary in areas where expertise is deficient.
• Work under regular exposure to zoonotic diseases, anesthetic agents, and cleaning chemicals.
• Strong interpersonal communication skills to effectively and diplomatically interact with physicians, staff, administration & sponsors.
• Experience managing complex projects is required as well
• Advanced knowledge of cell culture, cell line development, bioreactor operation and scale-up, centrifugation and ultracentrifugation, tangential flow and normal flow filtration
• Expert in flow cytometry, protein, mRNA, DNA characterization
• Excellent record keeping skills and good documentation practices.
• Demonstrated ability to work independently and collaboratively with multiple departments while utilizing innovation to elicit compliance.
• Demonstrated ability to carry out analytical tasks, to identify and define issues and alternatives, to resolve problems, and to draw logical conclusions.
• Demonstrated skill in gathering pertinent data, preparing narrative reports, statistical reports, charts, graphs, and tables.
• Demonstrated skill in reviewing documents, data and material compiled by others for completeness and accruacy to ensure that incorrect/incomplete data is corrected.
• Ability to deal with and maintain confidential and sensitive information with discretion.
• Demonstrated skill in good decision making and taking appropriate action in situations where no established criteria exists or where answers to problems are not readily available.
• Ability to work on a diverse variety of projects simultaneously, organize multiple projects for efficiency and cost-effectiveness.
• Demonstrated skill in prioritizing workflow to meet deadlines, often under pressure of conflicting demands, while maintaining accuracy and effectiveness of work.
• Ability to attend off-site staff meetings, conferences and investigator meetings.
• Ability to write concise and accurate administrative reports, policies, procedures, and correspondence.
• Working knowledge of some medical and scientific terminology for protocol abstracting and conversation with research personnel.
• Demonstrated skill in records management. Skill in establishing and maintaining complex filing systems.
• Demonstrated skills with personal computers, spreadsheets, databases and word processing applications for the maintenance of records, analysis of data, and the preparation of reports.

As a condition of employment, the final candidate who accepts an offer of employment will be required to disclose if they have been subject to any final administrative or judicial decisions within the last seven years determining that they committed any misconduct; or have filed an appeal of a finding of substantiated misconduct with a previous employer. Current/former UC employees are subject to a personnel file review.