Lead Liver MPS Scientist, Precision Medicine & Omics

University of Pittsburgh; Pittsburgh (Allegheny County); On-site; USD 90,000 - 130,000; Full time

Job summary

The University of Pittsburgh Liver MPS Team, part of OPTIn, seeks a PhD-level Research Scientist to lead translational research at the interface of microphysiological systems, systems biology, and precision medicine. You will work with patient-derived cells and iPSCs to stratify patients and test therapies in liver MPS platforms.

Responsibilities include experimental design, data analysis, mentoring, and collaboration with computational modelers to develop a preclinical trial-on-chip platform

Qualifications

• Ph.D. in cell biology, biomedical engineering, pharmacology, systems biology, or a related field.
• Hands-on experience with microphysiological systems (MPS) and omics-based, imaging-based, and biochemical readouts.
• Experience with complex cell culture models, including 3D cultures, multicellular co-cultures, organoids, primary cells, and/or iPSC-derived cells.
• Experience with iPSC generation and differentiation into hepatic cells.
• Proven ability to lead research projects with first-author publications and presentations.
• Experience training and mentoring junior scientists.
• Experience with liver biology and liver MPS models.
• Experience in transcriptomic/genomic/metabolomic data analysis; familiarity with precision medicine.

Responsibilities

• Lead MPS research projects from hypothesis development to data interpretation and dissemination.
• Design and perform experiments in multiple 3D liver MPS platforms using patient-derived cells.
• Apply omics-based, imaging-based, and biochemical assays to quantify phenotypes and drug responses.
• Train and mentor students, trainees, and technical staff in MPS methods.
• Integrate multi-omics datasets to elucidate disease mechanisms and stratify drug responses.
• Collaborate with computational modelers to translate findings into clinically actionable strategies.

Skills

MPS experiments

Multi-omics analysis

3D culture models

iPSC-derived hepatic cells

Data analysis

Mentoring junior scientists

Education

Ph.D. in relevant field

Tools

RNA-seq analysis

Metabolomics analysis

Job description

The University of Pittsburgh Liver MPS Team, part of OPTIn, seeks a PhD-level Research Scientist to lead translational research at the interface of microphysiological systems, systems biology, and precision medicine. You will work with patient-derived cells and iPSCs to stratify patients and test therapies in liver MPS platforms.

Responsibilities include experimental design, data analysis, mentoring, and collaboration with computational modelers to develop a preclinical trial-on-chip platform