Lead Drug Product Development Engineer

Nurix Therapeutics; Brisbane (CA); On-site; USD 195,000 - 223,000; Full time

Job summary

Nurix Therapeutics in Brisbane, CA seeks a Principal Engineer, Pharmaceutical Development Engineering to own hands-on engineering that turns a promising molecule into a manufacturable drug product. You will lead process development, scale-up, and CDMO operations for late-stage clinical and commercial programs.

This high-autonomy role requires expertise in GMP DP manufacturing, tech transfer to CDMOs, QBD and DOE studies, and regulatory CMC contributions.

Qualifications

• Ph.D. in chemical engineering or related field with 8+ years in late-stage small-molecule DP development.
• Extensive GMP DP manufacturing experience including spray drying, tableting, encapsulation.
• Experience with tech transfer to CDMOs and QBD/DOE studies.
• Strong cross-functional collaboration and regulatory familiarity (FDA/EMA/ICH).

Responsibilities

• Provide engineering leadership for process development and scale-up for DP.
• Oversee CDMO equipment engineering, tech transfer, and process validation.
• Coordinate with QA, Development, and Supply Chain for timely DP release.
• Contribute to regulatory filings (CMC sections) and inspection readiness.
• Mentor scientists and engineers; travel up to 25%.

Skills

Process development

CDMO management

Tech transfer

DOE studies

QBD

GMP knowledge

Scale-up

Education

Ph.D. in chemical engineering or related field

M.S. in chemical engineering (or related field)

B.S. in chemical engineering (or related field)

Job description

Nurix Therapeutics in Brisbane, CA seeks a Principal Engineer, Pharmaceutical Development Engineering to own hands-on engineering that turns a promising molecule into a manufacturable drug product. You will lead process development, scale-up, and CDMO operations for late-stage clinical and commercial programs.

This high-autonomy role requires expertise in GMP DP manufacturing, tech transfer to CDMOs, QBD and DOE studies, and regulatory CMC contributions.