Associate Director, Chemical Engineering – DS Scale-Up Lead

NURIX; San Francisco (CA); On-site; USD 190,000 - 217,000; Full time

Job summary

Nurix Therapeutics in Brisbane, CA is seeking an Associate Director, Chemical Engineering to provide end-to-end DS manufacturing leadership for bexobrutideg (NX-5948) from late-stage development through commercial launch.

You will lead scalable DS routes, oversee CDMO equipment qualification, drive tech transfer, and ensure cGMP compliance while partnering with CMC teams to optimize process robustness and cost of goods.

Qualifications

• PhD in chemical engineering with 5+ years in late-stage DS development.
• Extensive GMP DS manufacturing, scale-up, and validation experience.
• Knowledge of solid-state properties, polymorphism, crystallization.
• CDMO management experience including tech transfer and DoE/QbD.

Responsibilities

• Lead design and scale-up of DS manufacturing routes.
• Oversee CDMO equipment qualification and maintenance.
• Coordinate tech transfer to CDMOs and QA/QC.
• Support regulatory CMC sections and Health Authority responses.
• Monitor KPIs and ensure on-time manufacturing and release.

Skills

Engineering leadership

Process modeling

Scale-up

DoE

QbD

CDMO management

Regulatory knowledge

GMP familiarity

Cross-functional collaboration

Education

Ph.D. in chemical engineering

MS in chemical engineering

BS in chemical engineering

Tools

GMP systems

DoE software

Process modeling tools

Job description

Nurix Therapeutics in Brisbane, CA is seeking an Associate Director, Chemical Engineering to provide end-to-end DS manufacturing leadership for bexobrutideg (NX-5948) from late-stage development through commercial launch.

You will lead scalable DS routes, oversee CDMO equipment qualification, drive tech transfer, and ensure cGMP compliance while partnering with CMC teams to optimize process robustness and cost of goods.