Lead Computational Protein Engineer: Antibody & Protein Design

Gables Search Group; Rockville (MD); Sur place; USD 140 000 - 190 000; Plein temps

Résumé du poste

Gables Search Group is seeking a Computational Protein Engineer in Rockville, Maryland to lead hands-on antibody and protein engineering programs. The role blends wet-lab experimentation with computational design tools to accelerate discovery and guide design decisions.

You will collaborate with structural biologists and computational scientists to translate modeling insights into experimental work, manage projects, and communicate progress to scientific stakeholders.

Qualifications

• PhD in biochemistry, molecular biology, protein science, or a related discipline.
• Industry experience conducting hands-on antibody or protein engineering research.
• Strong expertise in protein expression, purification, characterization, and assay development.
• Experience with bispecific antibodies, nanobodies, multispecific proteins, or similar modalities.
• Familiarity with computational protein design and structure-prediction platforms.
• Scientific contributions demonstrated through publications, patents, or successful development programs.
• Ability to lead technical projects and collaborate across scientific disciplines.

Responsabilités

• Lead antibody and protein engineering programs, including affinity maturation, multispecific antibodies, and novel binder development.
• Develop protein expression, purification, and analytical characterization workflows across multiple formats.
• Design binding, biochemical, and functional assays to evaluate engineered candidates.
• Apply tools such as AlphaFold, Rosetta, and ProteinMPNN to prioritize designs and guide laboratory strategies.
• Partner with structural biologists and computational scientists to translate modeling insights into experimental programs.
• Provide technical leadership across complex, multidisciplinary research initiatives.
• Communicate findings, recommendations, and project progress to scientific stakeholders.

Connaissances

Hands-on protein engineering

Leadership

Collaboration across disciplines

Formation

PhD in biochemistry, molecular biology, protein science

Outils

AlphaFold

Rosetta

ProteinMPNN

Description du poste

Gables Search Group is seeking a Computational Protein Engineer in Rockville, Maryland to lead hands-on antibody and protein engineering programs. The role blends wet-lab experimentation with computational design tools to accelerate discovery and guide design decisions.

You will collaborate with structural biologists and computational scientists to translate modeling insights into experimental work, manage projects, and communicate progress to scientific stakeholders.