Lead Computational Protein Engineer: Antibody & Design

Accounting Search; Rockville (MD); Sur place; USD 130 000 - 170 000; Plein temps

Résumé du poste

Accounting Search is seeking a Computational Protein Engineer to lead hands-on experimental programs while leveraging computational tools to accelerate design cycles in Rockville, MD. The role combines wet-lab execution with cutting-edge computational design to advance antibody and protein engineering projects.

The ideal candidate has a PhD and deep experience in protein expression, purification, and characterization, plus a track record in antibody formats and publications or patents.

Qualifications

• PhD in biochemistry, molecular biology, protein biochemistry, or related discipline.
• Hands-on expertise in protein expression, purification, and characterization.
• Experience with antibody engineering formats including bispecifics, nanobodies, or related modalities.
• Peer-reviewed publications and/or patents in antibody or protein engineering.
• Familiarity with computational design tools (AlphaFold, Rosetta, ProteinMPNN) a plus.
• Proven ability to lead technical teams and manage complex, multi-faceted projects.
• Outstanding written and verbal communication skills.

Responsabilités

• Lead experimental design and execution of antibody and protein engineering programs including affinity maturation, multi-specific antibody development, and de novo binder design
• Drive protein expression, purification, and characterization workflows across multiple formats
• Design and execute binding and functional assays to evaluate and iterate on engineered proteins
• Collaborate with structural biologists and computational scientists to integrate structural insights into experimental programs
• Apply computational tools such as AlphaFold and Rosetta to support and inform wet lab strategies

Connaissances

Protein engineering

Computational design

Leadership

Formation

PhD in Biochemistry / Molecular Biology

Outils

AlphaFold

Rosetta

ProteinMPNN

Description du poste

Accounting Search is seeking a Computational Protein Engineer to lead hands-on experimental programs while leveraging computational tools to accelerate design cycles in Rockville, MD. The role combines wet-lab execution with cutting-edge computational design to advance antibody and protein engineering projects.

The ideal candidate has a PhD and deep experience in protein expression, purification, and characterization, plus a track record in antibody formats and publications or patents.