Lead Computational Protein Engineer for Antibody Design

True North Consultants, Inc.; Rockville (MD); On-site; USD 150,000 - 230,000; Full time

Job summary

True North Consultants, Inc. in Rockville, MD is seeking a Computational Protein Engineer to build and lead hands-on experimental programs while leveraging computational tools to accelerate and inform design cycles.

You will drive protein expression, purification, and characterization workflows across multiple formats; design and execute binding and functional assays; collaborate with structural biologists and computational scientists to integrate structural insights; and apply AlphaFold and

Qualifications

• PhD in biochemistry, molecular biology, protein biochemistry or related field.
• Hands-on expertise in protein expression, purification, and characterization.
• Experience with antibody engineering formats including bispecifics, nanobodies, or related modalities.
• Peer-reviewed publications and/or patents in antibody or protein engineering.
• Familiarity with computational design tools (AlphaFold, Rosetta, ProteinMPNN) a plus.
• Proven ability to lead technical teams and manage complex projects.
• Outstanding written and verbal communication skills.

Responsibilities

• Lead experimental design and execution of antibody and protein engineering programs including affinity maturation, multi-specific antibody development, and de novo binder design.
• Drive protein expression, purification, and characterization workflows across multiple formats.
• Design and execute binding and functional assays to evaluate and iterate on engineered proteins.
• Collaborate with structural biologists and computational scientists to integrate structural insights into experimental programs.
• Apply computational tools such as AlphaFold and Rosetta to support and inform wet lab strategies.

Skills

Protein expression

Antibody engineering

Leadership

Communication

Education

PhD in biochemistry, molecular biology, protein biochemistry

Tools

AlphaFold

Rosetta

ProteinMPNN

Job description

True North Consultants, Inc. in Rockville, MD is seeking a Computational Protein Engineer to build and lead hands-on experimental programs while leveraging computational tools to accelerate and inform design cycles.

You will drive protein expression, purification, and characterization workflows across multiple formats; design and execute binding and functional assays; collaborate with structural biologists and computational scientists to integrate structural insights; and apply AlphaFold and