Lead Clinical Scientist, Early Respiratory Development

Merck; Boston (MA); On-site; USD 260,000 - 410,000; Full time

Job summary

Merck invites applications for a physician-scientist to join Translational Medicine as Principal Scientist (Clinical Director) in Early Clinical Development for Respiratory Diseases, based in Boston, MA.

The role leads cross-functional teams, designs early clinical studies, develops biomarkers, and advances therapeutic programs from preclinical through Phase 2. MD or MD/PhD required; pulmonology fellowship preferred; travel ~25%.

Qualifications

• MD or MD/PhD required or international equivalent.
• Fellowship training in Pulmonology or related respiratory discipline preferred.
• Demonstrated record of scientific scholarship and publications.

Responsibilities

• Lead cross-functional teams to advance novel respiratory therapeutics from preclinical to early clinical development.
• Design and execute early clinical pharmacology studies across phases I–IV.
• Develop and validate clinical biomarkers using imaging, bio-sampling, and functional readouts.
• Collaborate with discovery, regulatory, biostatistics, and global trials teams.
• Support regulatory filing with data packages and presentations.
• Engage with scientific community through publications and conferences.

Skills

Allergy and Immunology

Asthma

Biomedical Research

COPD

Clinical Development

Clinical Medicine

Clinical Research

Clinical Trial Planning

Cross-Functional Teamwork

Pulmonary Disease Research

Pulmonary Disorders

Pulmonology

Translational Research

Education

MD or MD/PhD

Job description

Merck invites applications for a physician-scientist to join Translational Medicine as Principal Scientist (Clinical Director) in Early Clinical Development for Respiratory Diseases, based in Boston, MA.

The role leads cross-functional teams, designs early clinical studies, develops biomarkers, and advances therapeutic programs from preclinical through Phase 2. MD or MD/PhD required; pulmonology fellowship preferred; travel ~25%.