Lead Clinical Investigator (MD/DO) — Pittsburgh

System One Clinical & Science; Pittsburgh (Allegheny County); On-site; USD 180,000 - 240,000; Full time

Benefits offered by this job

Health insurance

401(k) plan

Job summary

System One Clinical & Science in Pittsburgh, PA is seeking an experienced Principal Investigator (MD or DO) to support a new clinical research site. You will provide medical oversight and serve as study physician, guiding eligibility, safety, and data quality.

Active Pennsylvania medical license and PI/Sub-Investigator experience are required, with strong clinical judgment and adherence to ICH-GCP and FDA regulations.

Qualifications

• MD or DO with a background in Internal Medicine, Family Medicine, or a Specialist.
• Active, unrestricted Pennsylvania medical license.
• Prior clinical research experience as a Principal Investigator or Sub-Investigator.
• Strong clinical judgment and commitment to participant safety.
• Familiarity with ICH-GCP and FDA clinical research regulations.

Responsibilities

• Provide medical oversight and clinical leadership for assigned clinical trials, ensuring patient safety and data quality.
• Serve as the study physician, reviewing participant eligibility and providing medical oversight of screening outcomes.
• Review adverse events (AEs), serious adverse events (SAEs), and participant safety trends.
• Perform or oversee study-specific medical assessments, including histories, physical exams, and endpoint assessments.
• Offer clinical guidance and oversight to site staff.

Skills

Clinical leadership

Medical judgment

Communication

Documentation

Education

MD/DO

Tools

FDA regulations

Job description

System One Clinical & Science in Pittsburgh, PA is seeking an experienced Principal Investigator (MD or DO) to support a new clinical research site. You will provide medical oversight and serve as study physician, guiding eligibility, safety, and data quality.

Active Pennsylvania medical license and PI/Sub-Investigator experience are required, with strong clinical judgment and adherence to ICH-GCP and FDA regulations.