Lead Biotech Drug Development Programs (Hybrid Boston)

Rapport Therapeutics; Boston (MA); On-site; USD 310,000 - 340,000; Full time

Benefits offered by this job

Unlimited PTO

Lifestyle spending account

Commuting reimbursement

Job summary

Rapport Therapeutics in Boston, MA is seeking a senior program leader to own two late-stage small molecule programs from late discovery through Phase 2. You will build and lead cross-functional teams across Discovery, Toxicology, CMC, Regulatory, Clinical, Biostatistics, and New Product Planning to align on strategy and study design.

You will partner with Regulatory Affairs to shape IND-enabling packages and interact with health authorities, translating data into clear go/no-go decisions for

Qualifications

• PhD, PharmD, MD, or equivalent advanced degree in a relevant scientific or clinical field.
• 15+ years of biotech/pharmaceutical industry experience with leadership in small molecule drug development.
• Significant experience leading cross-functional programs from discovery through IND submission and early development.
• Strong understanding of regulatory pathways and expectations for small molecule therapeutics.
• Exceptional interpersonal, communication, and influencing skills.
• Strong scientific fluency across pharmacology, toxicology, and clinical development.
• Track record operating effectively in small, resource-constrained organizations.
• Excellent executive communication skills; experience presenting to senior leadership and boards.

Responsibilities

• Serve as the single accountable leader for two assigned programs (RAP-641 and one other) from late discovery and IND-filing and through Phase 1 and Phase 2 clinical trials.
• Build and lead cross-functional program teams (Discovery, Toxicology, CMC, Regulatory, Clinical, Biostatistics,New Product Planning) to align on target product profile,integrateddevelopmentstrategy, andkey study designsthatalign with corporate goals and regulatory expectations.
• Partner with Regulatory Affairs to shape IND-enabling package strategy and pre-IND/IND interactions with health authorities
• Translate preclinical and translational data into clear go/no-go criteria and decision frameworks for governance bodies and the executive team
• Partner with Program Managersto develop and manage integrated program timelines, budgets, and risk registers; proactivelyidentify and mitigate technical, regulatory, and operational risks
• Serve as the primary internal voice of the program in portfolio reviews, board updates, and investor-facing materials, in partnership with Commercial and IR
• Build strong relationships with key internal stakeholders and external partners (CROs, CDMOs, consultants, etc.)
• Mentor junior program management staff and help build program management capability as the organization scales

Skills

PhD/MD/PharmD

15+ years biotech

Cross-functional leadership

Regulatory knowledge

Interpersonal communication

Pharmacology/toxicology knowledge

Executive communication

Ambiguity tolerance

Job description

Rapport Therapeutics in Boston, MA is seeking a senior program leader to own two late-stage small molecule programs from late discovery through Phase 2. You will build and lead cross-functional teams across Discovery, Toxicology, CMC, Regulatory, Clinical, Biostatistics, and New Product Planning to align on strategy and study design.

You will partner with Regulatory Affairs to shape IND-enabling packages and interact with health authorities, translating data into clear go/no-go decisions for