Lead Biostatistician (Oncology Clinical Studies)

Natera; United States; Remote; USD 131,000 - 164,000; Full time

Job summary

Natera is seeking a Lead Biostatistician in the United States to independently lead design, analysis, and reporting for multiple oncology trials, proposing fit-for-purpose designs with broad impact across the oncology portfolio.

The ideal candidate brings deep statistical expertise, strong scientific communication skills, and a proven track record of applying innovative methodologies to oncology clinical trial design in a fast-paced, cross-functional environment. Remote USA option is available.

Qualifications

• Ph.D. preferred in Biostatistics or related field.
• 4+ years of clinical trial biostatistics experience.
• Expertise in time-to-event analysis and advanced survival modeling.
• Experience with adaptive and biomarker-informed design.
• Familiarity with ICH, GCP, and CDISC SDTM/ADaM.
• Proficient in R.

Responsibilities

• Lead the statistical design and analytical planning for oncology studies.
• Collaborate with clinical, medical, and translational partners to influence study planning and execution.
• Author and review SAPs and reports (TLFs, CSRs, publications).
• Mentor junior statisticians and improve departmental processes.

Skills

Time-to-event

Adaptive design

Biostatistics

R programming

CDISC SDTM/ADaM

ICH GCP

Biomarker design

Cross-functional

Communication

Mentoring

Education

Ph.D. in Biostatistics

Tools

R

Job description

Location: United States

This is an exciting opportunity for a highly experienced, independent clinical biostatistician to advance adoption of Natera’s oncology portfolio of cutting-edge molecular diagnostic tests. As a Lead Biostatistician, you will independently lead the design, analysis, and reporting for multiple practice-changing oncology clinical trials. You will propose efficient, fit-for-purpose study designs with broad impact across the oncology portfolio.

The ideal candidate brings deep statistical expertise, strong scientific communication skills, and a proven track record of applying innovative methodologies to oncology clinical trial design in a fast-paced, cross‑functional environment.

PRIMARY RESPONSIBILITIES

• Study Design and Statistical Strategy: Lead the statistical design and analytical planning for oncology clinical utility studies. Provide technical expertise in complex study design methodologies and data analyses. Propose and justify efficient study designs tailored to complex oncology use cases.
• Cross‑Functional Collaboration: Serve as study statistician for multiple studies. Collaborate with clinical, medical, and translational partners to influence study planning, development, and execution. Identify risks, proactively communicate concerns, and champion solutions to interdisciplinary teams and executive leaders.
• Documentation and Reporting: Author and review high-quality statistical deliverables, including statistical analysis plans (SAPs), and reports (TLFs, CSRs, publications) for cross‑functional collaborators and stakeholders.
• Innovation and Improvement: Recommend and apply novel statistical approaches where appropriate. Mentor early career statisticians and support continuous improvement of departmental processes, tools, and templates to enhance team efficiency and analytical rigor. Collaborate on manuscripts for publications.

QUALIFICATIONS

• Advanced degree in Biostatistics, Statistics, or a related quantitative field (Ph.D. preferred).
• 4+ years of experience in clinical trial biostatistics.
• Strong expertise in time-to-event analysis, including handling of censoring, competing risks, and advanced survival modeling approaches commonly used in oncology.
• Expertise with innovative study design (e.g. adaptive and biomarker-informed design), power calculations, and endpoint evaluation.
• Working knowledge of ICH and GCP guidelines as well as CDISC standards (e.g. SDTM, ADaM).
• Proficient in R.

KNOWLEDGE, SKILLS, AND ABILITIES

• Expert-level ability to independently design clinical studies, grounded in deep domain knowledge and a nuanced understanding of complex, oncology‑specific challenges.

• Experience with biomarker enabled clinical study designs, sample size determination, and endpoint evaluation.

• Demonstrated ability and enthusiasm for working in fast‑paced, cross‑functional environments with collaborators from diverse technical backgrounds.

• Ability to communicate complex statistical concepts clearly to both technical and non-technical audiences.

• Preferred qualifications:

  • Working-knowledge of NGS-based diagnostics and ctDNA/MRD.
  • Experience with non-inferiority studies.

The pay range is listed and actual compensation packages are based on a wide array of factors unique to each candidate, including but not limited to skill set, years & depth of experience, certifications and specific office location. This may differ in other locations due to cost of labor considerations.

Remote USA

$130,900-$163,600 USD

OUR OPPORTUNITY

Natera™ is a global leader in cell‑free DNA (cfDNA) testing, dedicated to oncology, women’s health, and organ health. Our aim is to make personalized genetic testing and diagnostics part of the standard of care to protect health and enable earlier and more targeted interventions that lead to longer, healthier lives.

The Natera team consists of highly dedicated statisticians, geneticists, doctors, laboratory scientists, business professionals, software engineers and many other professionals from world‑class institutions, who care deeply for our work and each other. When you join Natera, you’ll work hard and grow quickly. Working alongside the elite of the industry, you’ll be stretched and challenged, and take pride in being part of a company that is changing the landscape of genetic disease management.

WHAT WE OFFER

Competitive Benefits - Employee benefits include comprehensive medical, dental, vision, life and disability plans for eligible employees and their dependents. Additionally, Natera employees and their immediate families receive free testing in addition to fertility care benefits. Other benefits include pregnancy and baby bonding leave, 401k benefits, commuter benefits and much more. We also offer a generous employee referral program!

For more information, visit www.natera.com.

Natera is proud to be an Equal Opportunity Employer. We are committed to ensuring a diverse and inclusive workplace environment, and welcome people of different backgrounds, experiences, abilities and perspectives. Inclusive collaboration benefits our employees, our community and our patients, and is critical to our mission of changing the management of disease worldwide.

If you are based in California, we encourage you to read this important information for California residents.

Link: https://www.natera.com/notice-of-data-collection-california-residents/