Lead Bioinformatician (cfDNA Algorithms and Pipelines)

Scorpion Therapeutics; United States; Remote; USD 131,000 - 164,000; Full time

Job summary

Scorpion Therapeutics is seeking a Lead Bioinformatician to develop algorithms for cfDNA-based diagnostic assays for Women’s and Organ health. You will design, benchmark, and deploy methods to detect variants in challenging sequencing contexts, including low-fraction samples, and guide call-sets and quality standards across teams.

The role emphasizes cross-functional collaboration with Variant Management, Reporting, and Laboratory Operations to ensure data quality and regulatory readiness in a

Qualifications

• Bachelor’s degree in Bioinformatics, Computational Biology, Human Genetics, or related field.
• 4+ years’ experience analyzing short-read sequencing data in regulated or production-adjacent settings.
• Proficiency in Python and experience benchmarking bioinformatics methods for difficult regions.

Responsibilities

• Lead algorithm development for cfDNA-based diagnostic assays.
• Benchmark callers and deploy computational methods for low-fraction samples.
• Collaborate with Variant Management, Reporting, and Laboratory Operations to ensure data quality and integration.

Skills

Python

cfDNA analysis

Genomics

Education

Bachelor’s degree in Bioinformatics, Computational Biology, Human Genetics, or related field

Job description

Role

Lead Bioinformatician specializing in developing algorithms for cfDNA-based diagnostic assays supporting Women’s and Organ health. Primary objectives involve designing, benchmarking, and deploying computational methods to accurately detect variants (SNVs, Indels, CNVs, SVs) in challenging sequencing contexts, such as low-fraction samples. Responsibilities include providing genomics insights for assay and panel development, strategizing caller creation and extension, troubleshooting complex production escalations, and collaborating cross-functionally with Variant Management, Reporting, and Laboratory Operations to ensure data quality and system integration. The role emphasizes defining scientific and technical standards for assay analysis, including AI-assisted investigations.

Qualifications

Bachelor’s degree in Bioinformatics, Computational Biology, Human Genetics, or related field; 4+ years’ experience analyzing short-read sequencing data in regulated or production-adjacent settings; proven contributions to sequencing assay workflows; proficiency in Python; experience developing or benchmarking bioinformatics methods for difficult regions; and familiarity with human genetics and variant spectrum considerations.

High-Value Biopharma Details

Focus on cfDNA testing for reproductive, prenatal, and organ health indications, with applications in diagnostics and screening. Emphasis on algorithmic development for complex variant detection, quality assurance, and production readiness in a high‑complexity, regulated laboratory environment. The position is remote within the USA, with compensation ranging from $130,900 to $163,600 based on experience.