Lead AI Engineer

Reboot Rx; United States; Teletrabalho; USD 120 000 - 180 000; Tempo integral

Vantagens oferecidas por esta oferta de emprego

Healthcare reimbursement

Unlimited PTO

14 company-wide holidays

Disability insurance

401(k) with Roth options

Resumo da oferta

Reboot Rx is a nonprofit startup focused on affordable cancer treatments through repurposed generic drugs. We seek a Lead AI Engineer to architect, build, deploy, and run our AI and data platform in a remote US role, collaborating with biomedical scientists to advance science.

You will own full-stack development (React frontend, Python backend), cloud infrastructure, data pipelines, and trustworthy AI systems with guardrails, retrieval-augmented generation, and human-in-the-loop review.

Qualificações

• Bachelor's degree in computer science, engineering, data science, or quantitative field (advanced degree preferred).
• Experience with biomedical or clinical data and knowledge bases (e.g., DrugBank, Open Targets, UMLS/MeSH).
• Track record of building AI/ML systems used by others; production experience with LLM apps and multi-agent orchestration.

Responsabilidades

• Partner with scientists to understand workflows and unmet needs; design and build innovative AI solutions.
• Shape technical strategy and roadmap for data and AI platform.
• Design, build, deploy, and run full-stack apps: React frontend, Python backend, cloud infra, data pipelines.
• Build agentic AI systems: multi-agent LLM pipelines with tool use, RAG, guardrails, and human-in-the-loop review.
• Architect and run AWS cloud infrastructure (Bedrock, Step Functions, ECS/Fargate, Lambda, Aurora/PostgreSQL, S3, OpenSearch) as code with security and observability.
• Communicate technical work to non-technical audiences and co-author publications with collaborators.
• Provide light IT support and mentorship to a small technical team.

Conhecimentos

Python

JavaScript/TypeScript

React

LLM/AI

AWS

Full-stack

Formação académica

Bachelor's degree in CS/Engineering/Data Science

Ferramentas

Docker

PostgreSQL

FastAPI

Descrição da oferta de emprego

Remote position with mission-driven cancer nonprofit startup

Company Overview: Reboot Rx is a nonprofit startup focused on advancing affordable cancer treatments by repurposing FDA-approved generic drugs (rebootrx.org). We synthesize and evaluate published clinical evidence on repurposed generic drugs for cancer in consultation with clinical experts, advance new clinical research through strategic partnerships, and develop and disseminate evidence-based information for clinicians, health systems, and other healthcare decision-makers.

Position description: The Lead AI Engineer serves as a strategic technology leader and hands-on contributor overseeing our data science and technology initiatives. This individual focuses on leveraging AI and ML to support scientific discovery and drive innovation, building on our success with prostate cancer so patients with other cancer types can benefit from repurposed therapies. This is a senior role for someone who still loves to code: you will architect, build, deploy, and run the AI systems at the core of our mission.

Responsibilities:

• Partner closely with biomedical scientists and other stakeholders to deeply understand their workflows and unmet needs, then design and build innovative solutions that solve their real problems and advance the science.
• Help shape and execute the technical strategy and roadmap for our data and AI platform.
• Design, build, deploy, and run software end-to-end: full-stack web applications (React front ends, Python API back ends), cloud infrastructure, and data pipelines.
• Build agentic AI systems: multi-agent LLM pipelines with tool use, retrieval-augmented generation, and guardrails that make outputs trustworthy (citation verification, hallucination mitigation, human-in-the-loop review).
• Architect and run cloud-native infrastructure on AWS (e.g., Bedrock, Step Functions, ECS/Fargate, Lambda, Aurora/PostgreSQL, S3, OpenSearch) as infrastructure-as-code, with cost-awareness, security, and observability at scale.
• Communicate technical work clearly to non-technical audiences, and co-author scientific publications with collaborators where appropriate.
• Wear multiple hats and provide light IT general support when needed.
• Provide technical leadership and mentorship to a small technical team.

Preferred skills and qualifications:

• Bachelor's degree in computer science, engineering, data science, or quantitative field (advanced degree preferred).
• Experience with biomedical or clinical data: the scientific literature and clinical-trial registries, drug/target/disease knowledge bases and ontologies (e.g., DrugBank, Open Targets, UMLS/MeSH).
• A track record of building AI/ML systems that others have used, in industry or in research.
• Demonstrable production experience building LLM applications including multi-agent orchestration, RAG, tool/function calling, prompt engineering, and evals and guardrails.
• Experience with cloud computing technologies (preferably AWS).
• Full stack experience: proficient in Python and modern JavaScript/TypeScript + React, with API frameworks (FastAPI/Flask), containerization (Docker), and relational databases (PostgreSQL).
• Excellent project management skills with the ability to communicate technical information to a wide audience.
• Self-directed and proactive, with the ability to identify priorities, take ownership, and drive work forward independently in a dynamic environment.
• Enthusiasm for Reboot Rx’s mission to improve outcomes for cancer patients.

Details:

Remote role. While Reboot Rx operates during typical Eastern Time work hours, the individual can live anywhere within the U.S. Benefits include healthcare reimbursement, an accommodating work schedule, unlimited paid time off (PTO) plus 14 company-wide holidays, short- and long-term disability insurance, and an employer-matched 401(k) retirement plan with Roth options. Reboot Rx is an equal opportunity employer. All candidates must be authorized to work in the U.S.

The Reboot Rx story: Founded in 2020, Reboot Rx is driven by a mission to help cancer patients worldwide have access to effective and affordable treatments that help them live longer and better lives. The Reboot Rx team and advisors are highly experienced industry leaders in cancer, drug development, AI, business, nonprofits, and policy. Many team members have been personally affected by cancer, which motivates the work we do each day. As a nonprofit funded by philanthropy, we can pursue the drugs with the greatest potential impact for patients, without needing a substantial financial return, and we can access partners and data that wouldn’t otherwise be possible.

We are a small organization with big ambitions, and we have achieved a lot in a short time thanks to numerous collaborations with prominent stakeholders. Our organization values patient-driven impact, scientific rigor, kindness and respect, open-mindedness and flexibility, and putting health and family first. We are a positive and supportive team committed to helping all staff develop and grow.