Laboratory Science Professional (Open Rank: Entry - Principal)

University of Colorado Anschutz Medical Campus; Aurora (CO); On-site; USD 46,000 - 80,000; Full time

Job summary

An established industry player is seeking a motivated Laboratory Science Professional to join their dynamic team. This role involves utilizing cutting-edge techniques such as NMR and cryo-EM to investigate macromolecular interactions related to diseases. The successful candidate will engage in molecular engineering, protein purification, and collaborate on innovative research projects. With a focus on scientific discovery, this position offers a unique opportunity to contribute to groundbreaking research in biochemistry and molecular genetics. If you're passionate about science and eager to make a difference, this role is for you!

Benefits

Health insurance

Life insurance

Retirement plans

Tuition benefits

Paid time off

ECO pass

Qualifications

• Bachelor's degree in a relevant field required.
• Experience in a wet lab environment preferred.

Responsibilities

• Perform experiments and analyze data using NMR and EM methods.
• Collaborate with investigators on laboratory functions.

Skills

Molecular engineering (PCR)

Recombinant protein expression and purification (FPLC, HPLC)

Gel electrophoresis (protein and DNA)

Nuclear Magnetic Resonance (NMR)

Cryo-electron microscopy (cryo-EM)

Education

Bachelor's degree in chemistry, biology, or related field

Tools

FPLC

HPLC

NMR

Cryo-EM

Job description

University Staff

Description

University of Colorado Anschutz Medical Campus

Department: Biochemistry & Molecular Genetics

Job Title: Laboratory Science Professional (Open Rank: Entry - Principal)

Position #:00833472 - Requisition #: 36652

Job Summary:	Our group takes an integrative approach that combines biophysical, biochemical, and biological methods to fully characterize macromolecular interactions that underlie disease progression. We utilize state-of-the-art techniques such as nuclear magnetic resonance (NMR) and cryo-electron microscopy (cryo-EM) to investigate atomic-resolution details of enzymes involved in infectious disease, cancer, and inflammation. Ongoing projects include: Bacterial proteases: Determining mechanisms of activation, protease specificity, and developing antimicrobial inhibitors. Bacterial metabolism: Characterizing novel metabolic enzymes. Cancer and inflammation: Investigating redox regulation and cellular signaling proteins. Enzyme dynamics: Studying allosteric mechanisms in key enzymes. We are seeking a laboratory professional at any level who is motivated to apply and expand a wide array of experimental techniques. Training in specialized methods such as NMR and cryo-EM will be provided as needed. Examples of Duties Performed Molecular engineering (PCR) Recombinant protein expression and purification (FPLC, HPLC) Gel electrophoresis (protein and DNA) Nuclear Magnetic Resonances (data collection, spectral assignments, relaxation experiments) EM/Cryo-EM (data collection, refinement) Additional Duties & Responsibilities: Collaborate with and support other investigators with laboratory and research functions Utilize a variety of laboratory techniques required for research projects Perform experiments and tabulate and analyze research Perform pre-analytical, analytical and post analytical test process and evaluate results produced Prepare lab for daily operations, including stocking materials, equipment, safety, cleanliness, and related areas Dispose of laboratory materials and samples using well established guidelines and instructions Review, complete and process logs, documents, databases, and related materials and information Assist in the review and implementation of lab support policies, practices and programs to meet organizational, operations and management needs Laboratory professionals in this position will work in an experimental (wet) lab environment, handling biological samples and analyzing data using NMR and EM methods, which require a strong level of computer skills. For more details, please visit: https://medschool.cuanschutz.edu/biochemistry/people/primary-faculty/eisenmesser-elan
Work Location:	Onsite - this role is expected to work onsite and is located in Aurora, CO.
Why Join Us:	Our department conducts research across a wide biological scale for fundamental scientific understanding with applications to many disease contexts. The overarching goal is to reach a level of molecular insight that helps develop therapeutic approaches to disease. As biochemists and molecular geneticists, we are amid an unprecedented time of discovery - our conception of the molecular biology of cells is going from the equivalent of grainy black-and-white to high-resolution technicolor. From deciphering the choreography of transcription complexes, chromosomes, and RNA molecules within cells to developing novel approaches to 3D molecular structure determination to understanding how viruses hijack a cell's machinery and alter its metabolome, the researchers in Biochemistry and Molecular Genetics (BMG) are at the forefronts of their fields both conceptually and technologically. The University of Colorado offers a comprehensive benefits package that includes health insurance, life insurance, retirement plans, tuition benefits, ECO pass, paid time off - vacation, sick, holidays and more. To see what benefits are available, please visit: https://www.cu.edu/employee-services/benefits-wellness.
Qualifications:	Minimum Qualifications: Entry Professional: Bachelor's degree in chemistry, biology, molecular biology or a related field A combination of education and related technical/paraprofessional experience may be substituted for the bachelor's degree on a year for year basis Intermediate Professional: Bachelor's degree in chemistry, biology, molecular biology or a related field A combination of education and related technical/paraprofessional experience may be substituted for the bachelor's degree on a year for year basis One (1) year professional level research experience Senior Professional: Bachelor's degree in biology, molecular biology, chemistry, genetics or related field A combination of education and related technical/paraprofessional experience may be substituted for the bachelor's degree on a year for year basis Two (2) years professional level research experience Principal Professional Bachelor's degree in biology, molecular biology, chemistry, genetics or related field A combination of education and related technical/paraprofessional experience may be substituted for the bachelor's degree on a year for year basis Three (3) years professional level research experience Required: Applicants must meet minimum qualifications at the time of hire. Preferred Qualifications: One (1) to Two(2)yearsof experience or background within an experimental or wet lab Prior experience in analytical chemistry, especially ultra-high pressure liquid chromatography coupled to mass spectrometry Competencies, Knowledge, Skills, and Abilities: Entry Professional: Knowledge of basic laboratory techniques including safety procedures and techniques Ability to communicate effectively, both in writing and orally Ability to establish and maintain effective working relationships with employees at all levels throughout the institution Ability to interpret and master complex research protocol information Intermediate Professional: Proficient knowledge of basic laboratory techniques including safety procedures and techniques Ability to communicate effectively, both in writing and orally Ability to establish and maintain effective working relationships with employees at all levels throughout the institution Ability to interpret and master complex research protocol information Senior Professional: Advanced knowledge of laboratory techniques including safety procedures and techniques Ability to communicate effectively, both in writing and orally Ability to establish and maintain effective working relationships with employees at all levels throughout the institution Ability to interpret and master complex research protocol information Principal Professional: Expert knowledge of laboratory techniques including safety procedures and techniques Expert ability to analyze and solve complex problems Ability to communicate effectively, both in writing and orally Ability to establish and maintain effective working relationships with employees at all levels throughout the institution Ability to interpret and master complex research protocol information Higher-level knowledge of Structural Biology, Instrumentation, and Computational Biology processes, functions and/or technology
How to Apply:	For full consideration, please submit the following document(s): 1.A letter of interest describing relevant job experiences as they relate to listed job qualifications and interest in the position. 2.Curriculum vitae / Resume 3.Three to five professional references, including name, address, phone number (mobile number if appropriate), and email address. Questions should be directed to: Elan Eisenmesser, [e-mail]
Screening of Applications Begins:	Immediately and continues until position is filled. For best consideration, apply by May 2, 2025
Anticipated Pay Range:	The starting salary range (or hiring range) for this position has been established as Entry Professional: $46,274- $58,861 Intermediate Professional: $50,357 - $64,054 Senior Professional: $54,440- $69,248 Principal Professional: $62,606 - $79,635 The above salary range (or hiring range) represents the University's good faith and reasonable estimate of the range of possible compensation at the time of posting. This position may be eligible for overtime compensation, depending on the level. Your total compensation goes beyond the number on your paycheck. The University of Colorado provides generous leave, health plans and retirement contributions that add to your bottom line. Total Compensation Calculator: http://www.cu.edu/node/153125
Equal Employment Opportunity Statement:	The University of Colorado (CU) is an Equal Opportunity Employer and complies with all applicable federal, state, and local laws governing non-discrimination in employment. We are committed to creating a workplace where all individuals are treated with respect and dignity, and we encourage individuals from all backgrounds to apply.
ADA Statement:	The University will provide reasonable accommodation to applicants with disabilities throughout the employment application process. To request an accommodation pursuant to the Americans with Disabilities Act, please contact the Human Resources ADA Coordinator at [e-mail].
Background Check Statement:	The University of Colorado Anschutz Medical Campus is dedicated to ensuring a safe and secure environment for our faculty, staff, students, and visitors. To assist in achieving that goal, we conduct background investigations for all prospective employees.
Vaccination Statement:	CU Anschutz strongly encourages vaccination against the COVID-19 virus and other vaccine preventable diseases. If you work, visit, or volunteer in healthcare facilities or clinics operated by our affiliated hospital or clinical partners or by CU Anschutz, you will be required to comply with the vaccination and medical surveillance policies of the facilities or clinics where you work, visit, or volunteer, respectively. In addition, if you work in certain research areas or perform certain safety sensitive job duties, you must enroll in the occupational health medical surveillance program.

Application Materials Required:Cover Letter, Resume/CV, List of References

Job Category:Research Services

Primary Location:Aurora

Department:U0001 -- Anschutz Med Campus or Denver-20085 - SOM-BioChem&Molecular Genetics

Schedule:Full-time

Posting Date:Apr 18, 2025

Unposting Date:Ongoing

Posting Contact Name:Elan Eisenmesser

Posting Contact Email:[e-mail]

Position Number:00833472