IMRE-0, Sr. Associate Scientist, Discovery Biology

EMD Serono, Inc.; Billerica (MA); On-site; USD 80,000 - 110,000; Full time

Job summary

Join a leading company as a Senior Associate Scientist in Discovery Biology, focusing on drug discovery for neurodegenerative diseases. Collaborate with an international team to develop innovative therapeutics and contribute to impactful research in a dynamic environment. Ideal candidates will have a strong background in biology and laboratory experience.

Qualifications

• Bachelor’s in Biology with 2+ years lab experience, or Master's with 1+ year, or Ph.D.
• Experience with human iPSC-derived neurons preferred.
• Strong skills in live-cell imaging and data analysis.

Responsibilities

• Develop and validate cell-based assays for drug candidate evaluation.
• Conduct biomarker discovery using patient samples.
• Record and analyze experimental data accurately.

Skills

Cell culture

Data analysis

Experimental design

Live-cell imaging

Communication

Education

Bachelor’s Degree in Biology

Master’s Degree in Biology

Ph.D. in Biology

Tools

qPCR

Western blotting

Graphpad Prism

Job description

IMRE-0, Sr. Associate Scientist, Discovery Biology

Join to apply for the IMRE-0, Sr. Associate Scientist, Discovery Biology role at EMD Serono, Inc.

Work Your Magic with us! Start your next chapter and join EMD Serono.

Ready to explore, break barriers, and discover more? We know you’ve got big plans – so do we! Our colleagues across the globe love innovating with science and technology to enrich people’s lives with our solutions in Healthcare, Life Science, and Electronics. Together, we dream big and are passionate about caring for our rich mix of people, customers, patients, and planet. That's why we are always looking for curious minds that see themselves imagining the unimaginable with us.

United As One for Patients, our purpose in Healthcare is to help create, improve and prolong lives. We develop medicines, intelligent devices and innovative technologies in therapeutic areas such as Oncology, Neurology and Fertility. Our teams work together across 6 continents with passion and relentless curiosity in order to help patients at every stage of life. Joining our Healthcare team is becoming part of a diverse, inclusive and flexible working culture, presenting great opportunities for personal development and career advancement across the globe.

Your Role

As a Senior Associate Scientist, you will contribute to the discovery of drugs for neurodegenerative/neuroinflammatory and autoimmune diseases. You will work collaboratively with an international team of scientists to develop novel therapeutics that align with the Neurology and Immunology portfolio. You will be responsible for the execution of in vitro cell-based assays that will further our mechanistic understanding of human neuroinflammatory diseases and evaluate potential drug candidates.

Responsibilities Include But Not Limited To

• Contribute to the development and validation of disease-relevant cell-based assays using human iPSC-derived neurons and glia, or cell lines to support target validation and drug candidate evaluation efforts.
• Conduct translational biomarker discovery using patient samples or disease-relevant cell-based assays to support pharmacodynamics and target engagement biomarker discovery, while also getting a deeper insight into the mechanisms of neuroinflammatory diseases.
• Operate a variety of laboratory equipment, including microscopes/automated imagers, flow cytometers, qPCR machines, and spectrophotometers.
• Record data accurately in the Electronic Laboratory Notebook and maintain records per company policy and legal requirements.
• Prepare data reports to lab head and give presentations at internal and external meetings.
• Independently design, execute, analyze, interpret, and troubleshoot experiments and data.
• Provide technical support to colleagues in own area of expertise when necessary.
• Work closely with members in RU-N&I to support departmental goals.

Who You Are

Minimum Qualifications:

• Bachelor’s Degree in Biology, Neurobiology, or other Life Science discipline with 2+ years of laboratory experience in Academia, Pharma, or CRO.

OR

• Master’s Degree in Biology, Neurobiology, or other Life Science discipline with 1+ years of laboratory experience in Academia, Pharma or CRO.

OR

• Ph.D. in Biology, Neurobiology, or other Life Science discipline.

Preferred Qualifications

• Experience in maintaining mammalian neuron and glia cell culture; specifically human iPSC-derived neurons and glia, or primary neurons or glia, in co-culture and triculture systems, utilizing neurodegenerative disease-relevant models or assays.
• Experience in transfection of cells to introduce siRNAs, ASO, or CRISPR-based gene editing tools to suppress or knockout specific genes.
• Experience in live-cell imaging and imaging analysis using an Incucyte or similar automated imager; Immunocytochemistry and/or RNAscope.
• Experience with Gene expression and protein analyses: DNA/RNA isolation, qPCR platforms (Applied biosystems QuantStudio, Nanostring, etc), western blotting (SallySue, Wes).
• Experience with Bioanalytical assays: AlphaLISA, Meso Scale Discovery (MSD).
• Experience in the pharmaceutical industry and drug discovery processes.
• Experience in independently designing and executing experiments in a self-motivated, proactive manner, utilizing scientific literature and input.
• Experience working effectively in fast-paced, high-functioning, cross-functional teams.
• Excellent skills in live-cell imaging and analysis, immunocytochemistry, and/or RNAscope.
• Excellent skills in research analytical software, including Graphpad Prism, Microsoft Office, FIJI (or similar image analysis software), and QuantStudio.
• Excellent verbal and written communication skills.

Note: The original description contains some repetitive sections and extraneous content (e.g., job listings, promotional text) that have been omitted for clarity and focus on the job role.