Hybrid IT Audit & Compliance Leader

Vertex Pharmaceuticals Inc (US); Boston (MA); Hybrid; USD 164,000 - 247,000; Full time

Benefits offered by this job

Annual bonus

Equity awards

Overtime pay (as applicable)

Job summary

Vertex Pharmaceuticals Inc. is seeking an Audit & Compliance Manager in Boston to coordinate IT-related audits, inspections, and remediation activities across Data, Technology & Engineering and business functions.

The role partners with Internal Audit, Quality Assurance, SOX PMO, system owners, and business teams to ensure audit commitments are met and compliance obligations fulfilled, with a hybrid work option and strong focus on governance and improvement.

Qualifications

• 5–8+ years of experience in IT Compliance, Quality, Internal Audit, SOX, GxP Compliance, or a related field.
• Experience supporting audits, inspections, and remediation activities in regulated environments.
• Working knowledge of GxP, CSV/CSA, 21 CFR Part 11, SOX, NIST SP 800-53, GDPR, General IT Controls, and audit methodologies.

Responsibilities

• Serve as the primary DTE point of contact for IT-related audit, inspection, and compliance requests across GxP, Internal Audit, and operational audit activities.
• Coordinate audit and inspection preparation activities, including stakeholder readiness, request management, evidence collection, and response tracking.
• Track audit findings, observations, CAPAs, management responses, action plans, and remediation commitments through closure.
• Oversee the compliance metrics dashboard, including ongoing enhancements to monitor audit readiness, remediation progress, compliance trends, and leadership objectives.

Skills

Internal Audit

SOX

GxP Compliance

IT Compliance

Quality Assurance

Audit methodologies

NIST SP 800-53

21 CFR Part 11

GDPR

General IT Controls

Contractors management

Remediation strategies

Dashboard metrics

Project management

Job description

Vertex Pharmaceuticals Inc. is seeking an Audit & Compliance Manager in Boston to coordinate IT-related audits, inspections, and remediation activities across Data, Technology & Engineering and business functions.

The role partners with Internal Audit, Quality Assurance, SOX PMO, system owners, and business teams to ensure audit commitments are met and compliance obligations fulfilled, with a hybrid work option and strong focus on governance and improvement.