DTE Audit & Compliance Lead — GxP, SOX & IT Controls

Vertex Pharmaceuticals Incorporated; Boston (MA); Hybrid; USD 164,000 - 247,000; Full time

Benefits offered by this job

Equity awards

Commuting subsidy

401(k)

Job summary

Vertex Pharmaceuticals Incorporated is seeking an Audit & Compliance Manager to lead IT audit, inspection, and compliance activities across Data, Technology & Engineering and business functions. The role acts as the primary liaison with auditors, coordinating readiness, evidence gathering, and remediation.

You will partner with Internal Audit, Quality Assurance, SOX PMO, system owners, and business teams to ensure audit commitments are met and compliance obligations fulfilled, with

Qualifications

• 5-8+ years of experience in IT Compliance, Quality, Internal Audit, SOX, or a related field.
• Experience supporting audits, inspections, and remediation activities in regulated environments.
• Working knowledge of GxP, CSV/CSA, 21 CFR Part 11, SOX, NIST SP 800-53, GDPR, General IT Controls, and audit methodologies.
• Experience overseeing contractors and managed service provider work.
• Experience developing and leading remediation or risk mitigation strategies.
• Experience gathering, analyzing, and reporting compliance metrics, including dashboard content and leadership reporting.
• Strong project management skills with the ability to manage work in a complex, matrixed organization.

Responsibilities

• Serve as the primary DTE point of contact for IT-related audit, inspection, and compliance requests across GxP, Internal Audit, and operational audit activities.
• Coordinate audit and inspection preparation activities, including stakeholder readiness, request management, evidence collection, and response tracking.
• Facilitate communication between DTE teams, business stakeholders, Quality Assurance, Internal Audit, SOX PMO, and external auditors or inspectors.
• Track audit findings, observations, CAPAs, management responses, action plans, and remediation commitments through closure.
• Oversee the compliance metrics dashboard, including ongoing enhancements to monitor audit readiness, remediation progress, compliance trends, and leadership objectives.
• Promote consistent audit preparation, evidence management, documentation, and remediation practices across DTE.
• Support health authority inspections and inspection readiness programs, including preparation of DTE SMEs and stakeholders.
• Coordinate IT-related internal operational audit activities for DTE.
• Drive assigned remediation/CAPA activities to timely closure.
• Lead remediation meetings and provide clear status reporting on open actions, risks, and closure plans.

Skills

IT Compliance

Quality Assurance

SOX

GxP

Project management

Effective communication

Tools

Audit management tools

Job description

Vertex Pharmaceuticals Incorporated is seeking an Audit & Compliance Manager to lead IT audit, inspection, and compliance activities across Data, Technology & Engineering and business functions. The role acts as the primary liaison with auditors, coordinating readiness, evidence gathering, and remediation.

You will partner with Internal Audit, Quality Assurance, SOX PMO, system owners, and business teams to ensure audit commitments are met and compliance obligations fulfilled, with