Histotechnologist

Proclinical Staffing; San Francisco (CA); On-site; USD 80,000 - 100,000; Full time

Job summary

Proclinical Staffing seeks a Histotechnologist in Newark, CA to support tissue processing, sectioning, staining, and imaging for drug discovery projects. The role requires FFPE and fresh-frozen workflows, H&E and IHC/IF/ISH assays, and experience with automated immunostaining platforms.

You will perform high-volume immunostaining, tissue embedding, sectioning with microtome/cryostat, and quality control across diverse tissue types, contributing to endpoint analyses and data interpretation.

Qualifications

• BS or MS in Biology, Biomedical Sciences, Histology, Pathology, Cell Biology, Molecular Biology, or related field.
• Approximately 3+ years of relevant histology experience in biotech, pharma, CRO, or academia.
• Experience with FFPE and fresh-frozen tissue workflows.

Responsibilities

• Preparation of tissue, including grossing and embedding.
• Sectioning tissue using microtome, cryostat, vibratome, and sliding-frozen microtome.
• High-volume automated immunostaining.
• Chromogenic and fluorescence immunodetection (single and multiplex).
• IHC, IF, and ISH assays, manual and automated workflows.

Skills

Histology

FFPE & Fresh-frozen workflows

Microtomy

Cryosectioning

H&E staining

Immunohistochemistry (IHC)

Immunofluorescence (IF)

ISH

Tissue processing

Automated immunostaining platforms

Education

BS or MS in Biology/Histology/Related field

Tools

Leica Bond RX

Biocare IntelliPATH

Automated slide stainers

Job description

Histotechnologist - Permanent - Newark, CA

Passionate about transforming tissue into breakthrough insights? Step into a role where your histology expertise drives real drug discovery impact.

We are seeking a Histotechnologist to join our client's dynamic team in CA, US.

Primary Responsibilities

The successful candidate will support research projects by performing histological procedures, including tissue preparation, sectioning, standard staining, immunostaining, imaging, and image quantification.

Skills & Requirements

• BS or MS in Biology, Biomedical Sciences, Histology, Pathology, Cell Biology, Molecular Biology, or a related scientific discipline.
• Approximately 3+ years of relevant histology experience in biotechnology, pharmaceutical, CRO, academic research, or a related laboratory environment.
• Demonstrated hands-on experience with FFPE and fresh-frozen tissue workflows.
• Strong experience with tissue processing, embedding, microtomy and/or cryosectioning, and histological staining.
• Experience performing H&E and immunohistochemical staining.
• Experience using microscopy to assess tissue morphology and staining quality.
• Experience operating and performing routine maintenance on histology laboratory equipment.
• ASCP certification (HT or HTL) is desirable
• Experience in performing, optimizing, and implementing qualitative and quantitative tissue-based methodologies, ranging from tissue handling and processing, sectioning with microtome or cryostat, and histochemical staining, is required
• Experience developing, optimizing, or troubleshooting IHC, IF, ISH, or other tissue-based assays.
• Experience with automated immunostaining platforms such as Leica Bond RX, Biocare IntelliPATH, or comparable systems.

Responsibilities

• Preparation of tissue, including grossing and embedding
• Sectioning tissue using various equipment, including cryostat, microtome, vibratome, and sliding-frozen microtome
• High-volume automated immunostaining
• Experience with chromogenic and fluorescence immunodetection (single and multiplex)
• Experience with automatic slide stainers such as Leica Bond Rx and Biocare IntelliPATH FLX is a plus
• Perform end-to-end histology workflows including tissue fixation, grossing, processing, embedding, sectioning, staining, imaging, and slide preparation.
• Work with both FFPE and fresh/frozen tissue samples across a variety of tissue types.
• Perform tissue sectioning using microtomes and cryostats; experience with additional sectioning platforms such as vibratomes or sliding microtomes is beneficial.
• Perform routine histological staining including H&E, nuclear counterstaining, and other special stains.
• Execute and support IHC, IF, and/or ISH assays, including both manual and automated staining workflows.
• Support single- and multiplex immunodetection using chromogenic and/or fluorescence-based methods

Compensation

• $80 000 - $100 000 Per Annum