Histotechnologist

Proclinical Group; San Francisco (CA); On-site; USD 80,000 - 100,000; Full time

Job summary

Proclinical Group is seeking a Histotechnologist for a permanent role in Newark, CA. You will transform tissue into insights by performing histology procedures, including tissue preparation, sectioning, staining, imaging, and quantification, to support drug discovery.

The ideal candidate has 3+ years of histology experience, a BS or MS in a related field, and hands-on FFPE/fresh-frozen workflows with experience in automated IHC platforms.

Qualifications

• Bachelor-level degree in biology, histology, pathology, cell biology or related field.
• 3+ years of histology experience in biotech, pharma, CRO or research labs.
• Hands-on with FFPE and fresh-frozen tissue workflows.
• Experience with tissue processing, embedding, microtomy and/or cryosectioning.
• Experience with H&E and immunohistochemical staining.
• Ability to use microscopy for morphology and staining quality.

Responsibilities

• Prepare tissue including grossing and embedding.
• Section tissue using microtome, cryostat, vibratome, and sliding microtome.
• Perform high-volume automated immunostaining.
• Support IHC/IF/ISH assays, manual and automated workflows.
• Perform routine histological staining (H&E, counterstains).
• Execute end-to-end histology workflows for FFPE and fresh tissue.

Skills

Histology expertise

IHC experience

Imaging & quantification

Sectioning & microtomy

FFPE & fresh-frozen workflows

Equipment maintenance

IHC/IF/ISH development

ASCP HT/HTL

Education

BS or MS in biology/related

Tools

Leica Bond RX

Biocare IntelliPATH

Cryostat / Microtome

Job description

Histotechnologist - Permanent - Newark, CA

Passionate about transforming tissue into breakthrough insights? Step into a role where your histology expertise drives real drug discovery impact.

We are seeking a Histotechnologist to join our client's dynamic team in CA, US.

Primary Responsibilities:

The successful candidate will support research projects by performing histological procedures, including tissue preparation, sectioning, standard staining, immunostaining, imaging, and image quantification.

Skills & Requirements:

• BS or MS in Biology, Biomedical Sciences, Histology, Pathology, Cell Biology, Molecular Biology, or a related scientific discipline.
• Approximately 3+ years of relevant histology experience in biotechnology, pharmaceutical, CRO, academic research, or a related laboratory environment.
• Demonstrated hands-on experience with FFPE and fresh-frozen tissue workflows.
• Strong experience with tissue processing, embedding, microtomy and/or cryosectioning, and histological staining.
• Experience performing H&E and immunohistochemical staining.
• Experience using microscopy to assess tissue morphology and staining quality.
• Experience operating and performing routine maintenance on histology laboratory equipment.
• ASCP certification (HT or HTL) is desirable
• Experience in performing, optimizing, and implementing qualitative and quantitative tissue-based methodologies, ranging from tissue handling and processing, sectioning with microtome or cryostat, and histochemical staining, is required
• Experience developing, optimizing, or troubleshooting IHC, IF, ISH, or other tissue-based assays.
• Experience with automated immunostaining platforms such as Leica Bond RX, Biocare IntelliPATH, or comparable systems.

The Histotechnologist's responsibilities will be:

• Preparation of tissue, including grossing and embedding
• Sectioning tissue using various equipment, including cryostat, microtome, vibratome, and sliding-frozen microtome
• High-volume automated immunostaining
• Experience with chromogenic and fluorescence immunodetection (single and multiplex)
• Experience with automatic slide stainers such as Leica Bond Rx and Biocare IntelliPATH FLX is a plus
• Perform end-to-end histology workflows including tissue fixation, grossing, processing, embedding, sectioning, staining, imaging, and slide preparation.
• Work with both FFPE and fresh/frozen tissue samples across a variety of tissue types.
• Perform tissue sectioning using microtomes and cryostats; experience with additional sectioning platforms such as vibratomes or sliding microtomes is beneficial.
• Perform routine histological staining including H&E, nuclear counterstaining, and other special stains.
• Execute and support IHC, IF, and/or ISH assays, including both manual and automated staining workflows.
• Support single- and multiplex immunodetection using chromogenic and/or fluorescence-based methods

Compensation:

• $80 000 - $100 000 Per Annum