HEOR Ops & Analytics Associate Director

Vertex US Distribution; United States; Hybrid; USD 172,000 - 258,000; Full time

Job summary

Vertex is seeking an Associate Director within HEOR’s Analytics CoE to support real-world evidence research using in‑licensed data assets. You will lead observational studies, plan analyses, and guide a team of statistical programmers to generate actionable insights for disease burden, costs, and treatment patterns.

This role offers flexible work arrangements (in-person, hybrid, or remote) and opportunities to shape product value strategies while collaborating across HEOR, Market Access, and the

Qualifications

• Advanced degree in health economics or a related quantitative discipline.
• Typically requires extensive experience in health economics and outcomes research.
• Strong knowledge of observational research methods and their application.

Responsibilities

• Lead development of study protocols, statistical analysis plans, and table shells.
• Collaborate with cross-functional teams to improve analytics operating models.
• Provide methodological expertise to research design and post-hoc analyses.
• Guide statistical programmers through data queries and analyses.
• Generate analytic reports and visualizations to communicate findings.

Skills

SAS programming

Excel

Observational research methods

Claims data analysis

EHR/EMR data analysis

Education

Advanced degree in health economics or related quantitative discipline

Tools

MarketScan

PharMetrics Plus

eLAAD+

Premier

Job description

Job Description

Vertex is seeking a talented and motivated individual with the desire to be part of a highly innovative company aimed at transforming the lives of people with serious diseases, their families and society. The Associate Director role is within HEOR’s Analytics Center of Excellence (CoE), a specialized team that provides strategic and technical support to HEOR, Market Access & Pricing, and the broader commercial organization. In this role, the Associate Director will primarily support HEOR disease/asset teams in real‑world observational and claims data research activities. The Associate Director will support colleagues looking to answer key questions that can be addressed using Vertex’s in‑licensed RWE data assets. This includes planning and conducting analyses to inform on questions related to disease prevalence, disease burden and progression, healthcare resource utilization and costs, and treatment patterns in ‘real world’ patient populations. The Associate Director is also expected to provide methodological expertise to research design, including development of study protocols, analysis plans, and table shells. This role will work closely with a team of statistical programmers to lead the execution of data queries and analyses. The Associate Director may also provide input to global product value strategy and tactics as well as provide input to design and interpretation of post‑hoc clinical trial analyses and evidence generation studies. The role has flexibility to be in‑person, hybrid, or remote.

Research Initiatives

Leverage Vertex’s in‑licensed RWE data assets to conduct queries and analyses to support the Vertex product portfolio and development programs across a range of therapeutic and disease areas. Research initiatives include the following:

• Conduct feasibility assessments to inform design and execution of research projects
• Conduct health economic and outcomes research to better characterize disease burden, healthcare resource utilization, co‑morbidities, and treatment patterns in ‘real world’ populations
• Generate actionable insights to address key business questions from internal and external stakeholders
• Lead the development of study protocols, statistical analysis plans, and table shells
• Support statistical programmers through the execution of data queries and analyses
• Generate analytic reports, tables, and visualizations to communicate research findings effectively to internal stakeholders
• Collaborate with cross‑functional colleagues to improve efficiency of current analytics operating model
• Contribute to the development, enhancement, and maintenance of internal analytic tools (e.g., programming libraries, reusable macros, table templates), to support the quality and consistency of data and analyses
• Support HEOR disease/asset leads in assessment of research gaps and evidence generation objectives that may be addressed through observational research

Requirements

• Advanced degree in health economics or a related quantitative discipline (such as mathematics, statistics, economics, epidemiology)
• Typically requires 8 years of relevant experience in health economics and outcomes research, or the equivalent combination of education and experience (e.g., Doctorate degree and 4 years of experience, Master’s degree and 6 years of experience)
• Strong knowledge of observational research methods and their application to studies assessing disease burden, healthcare resource utilization, treatment patterns, comorbidities, and health outcomes studies in real‑world patient populations
• Demonstrated experience applying claims‑based analytic methods in epidemiologic research, including disease prevalence estimation and evaluation of patient populations, using real‑world data sources
• Hands‑on experience analyzing large patient‑level healthcare datasets, including open and closed claims, EHR/EMR data, and hospital chargemaster data (e.g., MarketScan, PharMetrics Plus, eLAAD+, Premier)
• Working knowledge of national healthcare coding systems, including diagnostic, procedure, and drug coding, as well as relevant healthcare system structures
• Advanced proficiency in SAS programming and Excel required
• Excellent written and oral communication skills, including the ability to clearly convey complex analytic findings to both technical and non‑technical audiences
• Ability to plan, organize, and manage multiple projects simultaneously in different therapeutic areas
• Ability to navigate and succeed in a fast‑paced, dynamic, and collaborative team‑based environment

Pay Range

Pay Range: $172,000 - $258,000

Disclosure Statement: The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job‑related factors permitted by law.

Benefits

At Vertex, our Total Rewards offerings also include inclusive market‑leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week‑long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation

Flex Designation: Remote‑Eligible

Flex Eligibility Status: In this Remote‑Eligible role, you can choose to be designated as:

1. Remote: work remotely five days per week and come into the office on occasion – you’re always welcome on‑site; or select 2. Hybrid: work remotely up to two days per week; or select 3. On‑Site: work five days per week on‑site with ad hoc flexibility.

Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation. Vertex is committed to equal employment opportunity and non‑discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E‑Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law. Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [e-mail]

Help Us Achieve Our Mission

Vertex is a global biotechnology company that invests in scientific innovation to create transformative medicines for people with serious diseases. The company has approved medicines that treat the underlying causes of multiple chronic, life‑shortening genetic diseases — cystic fibrosis, sickle cell disease and transfusion‑dependent beta thalassemia — and continues to advance clinical and research programs in these diseases. Vertex also has a robust clinical pipeline of investigational therapies across a range of modalities in other serious diseases where it has deep insight into causal human biology, including APOL1‑mediated kidney disease, acute and neuropathic pain, type 1 diabetes, myotonic dystrophy type 1 and alpha‑1 antitrypsin deficiency. Founded in 1989 in Cambridge, Mass., Vertex’s global headquarters is now located in Boston’s Innovation District and its international headquarters is in London. Additionally, the company has research and development sites and commercial offices in North America, Europe, Australia, Latin America and the Middle East. Vertex is consistently recognized as one of the industry's top places to work, including 14 consecutive years on Science magazine’s Top Employers list and one of Fortune’s 100 Best Companies to Work For. For company updates and to learn more about Vertex’s history of innovation, visit www.vrtx.com or follow us on Facebook, Twitter/X , LinkedIn, YouTube and Instagram. The diversity and authenticity of our people is part of what makes Vertex unique, and we recognize that each employee brings diverse perspectives and strengths. By embracing those strengths and celebrating differences, we are fostering an inclusive culture where each of us can bring our authentic selves to work, inspire innovation together, and change people’s lives. Our vision is clear: to be the place where an authentic, diverse mix of talent want to come, to stay, and do their best work.