Head of LNP Formulation and RNA Delivery (In Vivo)

Kernal Biologics, Inc.; Cambridge (MA); On-site; USD 260,000 - 380,000; Full time

Benefits offered by this job

Free parking

Subway pass

Commuter rail pass

Bluebike membership

Flexible Spending Account

Paid parental leave

Life insurance

On-site cafeteria

Generous vacation/sick time

Job summary

Kernal Bio is seeking an experienced leader to direct the in vivo mRNA delivery program. You will report to the SVP of R&D and oversee the development of next-generation LNP systems for targeted, immuno-oncology and immunology applications.

The ideal candidate will guide a growing team, drive collaborations, ensure milestones are met, and contribute to regulatory and IP documents while advancing cutting-edge RNA delivery science.

Qualifications

• PhD in chemical engineering, organic chemistry or a related field.
• 8-10 years hands-on experience with lipid nanoparticle systems for mRNA and/or siRNA delivery.
• Experience with targeted LNPs and conjugation of biomaterials.
• Experience with analytical techniques for LNPs such as HPLC/UPLC, LC-MS, DLS, UV-Vis, fluorescence spectrophotometry, Ribogreen assay, gel electrophoresis, capillary electrophoresis, flow cytometry.

Responsibilities

• Oversee the development of novel LNP compositions.
• Improve existing LNP formulations.
• Manage company’s LNP team.
• Advance targeted LNP delivery with novel approaches for in situ mRNA delivery.
• Oversee physicochemical characterization of LNP formulations.
• Work closely with internal teams and external collaborators and ensure delivery on key milestones.
• Guide company’s RNA delivery strategy, with a particular emphasis on IP and key deliverables.
• Stay up-to-date on RNA delivery literature and prepare technical reports and white papers.
• Prepare technical documents and manuscripts for regulatory filings, IP prosecution, and publications.
• Present scientific findings internally and externally at scientific conferences and industry events.

Skills

Communication

Leadership

Team player

Problem solving

Startup mindset

Learning agility

Education

PhD in chemical engineering

Tools

HPLC/UPLC

LC-MS

DLS

UV-Vis

Flow cytometry

RiboGreen

Gel electrophoresis

Capillary electrophoresis

Job description

Kernal Bio is seeking an experienced leader to direct the in vivo mRNA delivery program. You will report to the SVP of R&D and oversee the development of next-generation LNP systems for targeted, immuno-oncology and immunology applications.

The ideal candidate will guide a growing team, drive collaborations, ensure milestones are met, and contribute to regulatory and IP documents while advancing cutting-edge RNA delivery science.