Head of Chemical Process R&D & Tech Transfer

Madrigal Pharmaceuticals, Inc.; Conshohocken (Montgomery County); On-site; USD 276,000 - 329,000; Full time

Benefits offered by this job

Equity

Comprehensive benefits

401(k) plan

Job summary

Madrigal Pharmaceuticals, Inc. in Conshohocken, PA seeks an Executive Director, Chemical Process R&D to define DS route and lead tech transfer to CDMOs, ensuring robust process controls and regulatory readiness.

The role demands 18+ years in process chemistry/DS development with external manufacturing, strong leadership, and clear CMC documentation across cross-functional teams. Excellent collaboration with Analytical Development and Engineering is required for phase-appropriate strategy and

Qualifications

• BS+ in Chemistry or related field; PhD preferred.
• 18+ years process chemistry/DS development with external manufacturing support.
• Leadership of route development, impurity strategy, and tech transfer.
• Strong technical writing and cross-functional leadership.

Responsibilities

• Process Strategy & Development: Define DS route and RSM strategy aligned with phase-appropriate control strategy; approve DS R&D plans; ensure DS deliverables support clinical supply and lifecycle readiness.
• Tech Transfer & External Manufacturing Support: Lead DS tech transfer to CDMOs; provide oversight for deviations, investigations, CAPA, and change impacts; drive continuous improvement.
• Cross-Functional Integration & Documentation: Partner with Analytical Development and Engineering on method needs, scale-up, safety, and equipment fit; contribute to CMC documents and health authority responses.

Skills

Process chemistry leadership

Tech transfer

Impurity control

Cross-functional leadership

Regulatory/CMC writing

Education

BS+ in Chemistry or related (PhD preferred)

Job description

Madrigal Pharmaceuticals, Inc. in Conshohocken, PA seeks an Executive Director, Chemical Process R&D to define DS route and lead tech transfer to CDMOs, ensuring robust process controls and regulatory readiness.

The role demands 18+ years in process chemistry/DS development with external manufacturing, strong leadership, and clear CMC documentation across cross-functional teams. Excellent collaboration with Analytical Development and Engineering is required for phase-appropriate strategy and