Executive Director, Process Chemistry R&D

Madrigal; Conshohocken (Montgomery County); On-site; USD 276,000 - 329,000; Full time

Benefits offered by this job

Equity

Comprehensive benefits

Paid time off

401(k) with employer match

Mental health support

Job summary

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH). The role focuses on defining DS route and RSM strategy, tech transfer, and cross-functional collaboration to support clinical supply and lifecycle readiness.

The successful candidate will bring 18+ years of process chemistry/DS development experience, with leadership in route development, impurity strategy, and external manufacturing partnerships.

Qualifications

• BS+ in Chemistry or related field; PhD preferred.
• 18+ years process chemistry/DS development with external manufacturing experience.
• Proven leadership of route development, impurity strategy, and tech transfer.
• Strong technical writing and cross-functional leadership.

Responsibilities

• Define DS route and RSM strategy aligned with phase-appropriate control strategy.
• Lead DS tech transfer expectations and readiness criteria for CDMOs.
• Provide technical oversight for deviations, investigations, CAPA, and change impacts.
• Drive continuous improvement initiatives (yield, cycle time, robustness).
• Partner with Analytical on method needs for process characterization and control strategy.
• Partner with Engineering on scale-up, safety, and equipment/process suitability.

Skills

process chemistry

DS development

tech transfer

external manufacturing

leadership

technical writing

cross-functional collaboration

Education

BS+ in Chemistry or related field

PhD preferred

Job description

Madrigal is a biopharmaceutical company focused on delivering novel therapeutics for metabolic dysfunction-associated steatohepatitis (MASH). The role focuses on defining DS route and RSM strategy, tech transfer, and cross-functional collaboration to support clinical supply and lifecycle readiness.

The successful candidate will bring 18+ years of process chemistry/DS development experience, with leadership in route development, impurity strategy, and external manufacturing partnerships.